Sex differences in cognitive processing in children treated with CNS prophylaxis for acute lymphoblastic leukemia.
Sex differences in cognitive processing in children treated with CNS prophylaxis for acute lymphoblastic leukemia.
复制标题
接受中枢神经系统预防治疗急性淋巴细胞白血病的儿童认知处理的性别差异。
DOI：
10.1093/jpepsy/15.1.105
复制
发表时间：
1990
影响因子：
3.6
通讯作者：
Sallan,SE
中科院分区：
文献类型：
--
作者：
Waber,DP;Gioia,G;Paccia,J;Sherman,B;Dinklage,D;Sollee,N;Urion,DK;Tarbell,NJ;Sallan,SE
评估51名儿童（27名女性，24名男性）的认知加工，这些儿童接受了急性淋巴细胞白血病（ALL）的中枢神经系统预防治疗（颅放射联合鞘内化疗），并连续无病5至12年。对照组包括15名接受Wilm肿瘤治疗的儿童。评估的功能包括视觉感知技能、组织策略的产生、对组织结构的敏感性和注意力。与实体瘤对照组相比，ALL组在欣赏复杂视觉空间材料的内在组织和警觉性方面表现出表现缺陷，女性比男性受到的影响更严重。男性在智商和学业成绩上的性别差异与这些认知过程有关。
Evaluated cognitive processing in 51 children (27 female, 24 male) who had been treated for acute lymphoblastic leukemia (ALL) with CNS prophylaxis (cranial radiation in combination with intrathecal chemotherapy) and were continuously disease-free for 5 to 12 years. The control group comprised 15 children treated for Wilm's tumor. Functions assessed included visuopercep-tual skills, generation of organizational strategies, sensitivity to organizational structure, and attention. The ALL group showed performance deficits relative to the solid tumor controls in appreciating the organization inherent in complex visuospatial material and alertness, with females more severely affected than males. Sex differences favoring males on IQ and academic achievement were related to these cognitive processes.