Relation between systemic hypertension and pain perception.
Relation between systemic hypertension and pain perception.
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全身性高血压与疼痛感知之间的关系。
DOI：
10.1016/0002-9149(92)90181-w
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Maixner,W
中科院分区：
文献类型：
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作者：
Sheps,DS;Bragdon,EE;Gray3rd,TF;Ballenger,M;Usedom,JE;Maixner,W
为了检验高血压降低疼痛感知的假设，进行了一项研究，评估了人类受试者的动脉血压和热疼痛感知之间的关系。研究的所有20名男性（10名高血压，10名血压正常）的平均动脉压被证明与热痛阈值（p = 0.05）和耐受性（p = 0.003）显著相关。正常血压组和高血压组之间的基线和测试后血浆β内啡肽水平的差异也是显著的（p = 0.02），并且表明内源性二倍体和血压之间的相互作用。本文还综述了近年来高血压与痛觉减退关系的其他研究。高血压大鼠与血压正常大鼠相比，痛阈增加。在猫中，迷走传入神经（心肺压力感受器）的电刺激抑制伤害感受性反应，并且血压和血管容积扩张的药理学升高都产生抗伤害感受性。这些结果与人类研究的初步结果一起表明，疼痛控制和心血管调节功能之间的相互作用可能是由压力感受器系统介导的。
To test the hypothesis that hypertension diminishes pain perception, a study was made that evaluated the relation between arterial blood pressure and thermal pain perception in human subjects. The average mean arterial pressure in all 20 men studied (10 hypertensive, 10 normotensive) proved to be significantly related to both thermal pain threshold (p = 0.05) and tolerance (p = 0.003). The difference between normotensive and hypertensive groups in baseline and posttest plasma levels of β endorphin was also significant (p = 0.02) and indicated an interaction between endogenous oploids and blood pressure. Other recent studies of hypertension in relation to hypalgesia were also reviewed. An increased pain threshold was found in hypertensive versus normotensive rats. In cats, electrical stimulation of vagal afferent nerves (cardiopulmonary baroreceptors) suppresses noclceptive responses, and both pharmacologic elevation of blood pressure and vascular volume expansion produce antinociperception. Together with preliminary findings in human studies, these results indicate an interaction between pain-controlling and cardiovascular regulatory functions that is probably mediated by the baroreceptor system.