Gender difference in brain perfusion 99mTc-ECD SPECT in aged healthy volunteers after correction for partial volume effects
Gender difference in brain perfusion 99mTc-ECD SPECT in aged healthy volunteers after correction for partial volume effects
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DOI：
10.1097/00006231-200410000-00003
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发表时间：
2004-10-01
影响因子：
1.5
通讯作者：
Tanaka, F
中科院分区：
文献类型：
--
作者：
Li, ZJ;Matsuda, H;Tanaka, F
背景先前的报道已经产生了关于区域脑血流（rCBF）性别差异的有争议的结果。为了阐明这一问题，我们比较了Tc-99m乙基半胱氨酸二聚体单光子发射计算机断层扫描（SPECT）图像在年龄匹配的健康男性和女性脑灌注校正后的部分体积效应（pve）。方法对40名健康右撇子受试者进行静息状态脑灌注SPECT扫描，其中男20名，女20名，年龄在58 ~ 86岁之间，无社会人口统计学差异。通过磁共振成像测量脑灰质体积进行PVE校正。采用统计参数映射法对调整后的rCBF图像进行相对流量分布分析。结果PVE校正显示，女性左侧额下回、双侧颞中回和左侧颞上回的rCBF较高。男性左侧额上回、右侧额内侧回、右侧顶叶上小叶、右侧中央后回、右侧小脑、右侧额中回、右侧梭状回和右侧楔前叶的rCBF较高。结论健康志愿者rCBF存在显著的性别差异。SPECT图像的PVE校正显示了性别差异，这与女性在语言任务和男性在视觉空间任务上表现更好的普遍发现是一致的。(C) 2004利平科特·威廉姆斯·威尔金斯。
Background Previous reports have yielded controversial results concerning gender differences in regional cerebral blood flow (rCBF). To elucidate this issue, we compared Tc-99m ethyl cysteinate dimer single photon emission computed tomography (SPECT) images for brain perfusion between aged-matched healthy men and women after correction for partial volume effects (PVEs).Methods Brain perfusion SPECT in the resting state was performed on 40 healthy, right-handed subjects, 20 men and 20 women, with an age range of 58-86 years, who did not differ sociodemographically. PVE correction was performed using grey matter volume measured by magnetic resonance imaging. Statistical parametric mapping was used for the analysis of the adjusted rCBF images of relative flow distribution.Results The PVE correction revealed that women had higher rCBF in left inferior frontal gyrus, bilateral middle temporal gyri, and left superior temporal gyrus. Men had higher rCBF in left superior frontal gyrus, right medial frontal gyrus, right superior parietal lobule, right postcentral gyrus, right cerebellum, right middle frontal gyrus, right fusiform gyrus, and right precuneus.Conclusion Significant gender differences in rCBF existed in these healthy volunteers. The PVE correction of SPECT images revealed gender differences that were consistent with the universal findings of better performance on verbal tasks in women and on visuospatial tasks in men. (C) 2004 Lippincott Williams Wilkins.