Genes, environment, and cardiovascular disease
Genes, environment, and cardiovascular disease
复制标题
DOI：
10.1161/01.atv.0000075081.51227.86
复制
发表时间：
2003-07-01
影响因子：
8.7
通讯作者：
Kardia, SLR
中科院分区：
文献类型：
--
作者：
Sing, CF;Stengård, JH;Kardia, SLR
在这篇文章中，我们提请注意每个医学研究人员都知道心血管疾病的病因，但在设计、实施和报告基因研究时大多数人否认或选择忽视。医学研究正在进入一个综合时代，它将利用过去十年还原论在定义和描述人类基因组变异方面所取得的成功。要深入了解这种变异的作用，需要一个基因组-表型关系的生物学模型，该模型将可能的遗传因素和环境因素之间的相互作用结合起来，作为由时间和空间索引的特定背景下的因果关系。我们就应对这些复杂性需要采取的措施提出建议。
In this essay, we call to attention what every medical researcher knows about the etiology of cardiovascular disease but most deny, or choose to ignore, when designing, carrying out, and reporting genetic studies. Medical research is entering an era of synthesis that will take advantage of the successes of reductionism over the past decade in defining and describing human genome variations. Meaningful insights into the role of such variation requires a biological model of genome-phenotype relationships that incorporates interactions between subsets of possible genetic and environmental agents as causations in particular contexts indexed by time and space. We make recommendations for what needs to be done to cope with these complexities.