The incidence of adult T-cell leukemia/lymphoma among human T-lymphotropic virus type 1 carriers in Japan
The incidence of adult T-cell leukemia/lymphoma among human T-lymphotropic virus type 1 carriers in Japan
复制标题
DOI：
10.3109/10428194.2014.964700
复制
发表时间：
2015-06-01
影响因子：
2.6
通讯作者：
Yamaguchi, Kazunari
中科院分区：
文献类型：
--
作者：
Satake, Masahiro;Yamada, Yasuaki;Yamaguchi, Kazunari
人类嗜T淋巴细胞病毒1型（HTLV-1）在日本九州/冲绳地区高度流行。一项全国性的调查证实了2007年至2008年首次献血者中HTLV-1携带者的频率和新诊断的成人T细胞白血病/淋巴瘤（ATL）病例的发生率。在调整了不同地区捕获率的差异后，确定了携带者中ATL的年龄、性别和地区特异性发病率。在九州和非九州/冲绳地区，10000名携带者的年ATL发病率分别为7.7和8.7。从40多岁到70多岁，男性的发病率急剧增加，但女性的发病率在40多岁到70多岁之间保持不变。即使假设女性携带者频率与男性相同，中年女性的ATL发病率仍然较低。60岁和70岁的ATL患者将占日本未来15年所有ATL患者的三分之二。
Human T-lymphotropic virus type 1 (HTLV-1) is highly endemic in the Kyushu/Okinawa region of Japan. A nationwide investigation verified the frequency of HTLV-1 carriers among first-time blood donors and the occurrence of newly diagnosed adult T-cell leukemia/lymphoma (ATL) cases from 2007 through 2008. After adjusting for differences in capture rate between areas, the age-, sex- and area-specific incidence of ATL among carriers was determined. Annual ATL incidence among 10 000 carriers was 7.7 and 8.7 for the Kyushu and non-Kyushu/Okinawa regions, respectively. The incidence increased sharply for men from their 40s to their 70s, but the rate in females remained unchanged through their 40s to 70s. ATL incidence in middle-aged females was still low, even if female carrier frequency was assumed to be identical to that of males. Patients with ATL in their 60s and 70s will comprise two-thirds of all patients with ATL for the next 15 years in Japan.