5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus
5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus
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DOI：
10.1016/s0006-8993(02)03477-7
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发表时间：
2002-11-15
期刊：
影响因子：
2.9
通讯作者：
Jacobs, BL
中科院分区：
文献类型：
--
作者：
Radley, JJ;Jacobs, BL
本研究观察了5-HT1a受体拮抗剂对成年大鼠齿状回细胞增殖的影响。三种拮抗剂(NaN-190、p-MPPI和Way-100635)均使齿状回中BrdU免疫反应阳性细胞的数量显著减少30%。这表明5-HT1a受体的活性在齿状回自然发生的细胞增殖过程中是重要的，也可能是神经发生过程中的重要因素，是参与其调节的众多因素之一。(C)2002 Elsevier Science B.V.保留所有权利。
This study investigated the action of 5-HT1A receptor antagonists on cell proliferation in the dentate gyrus of adult rats. Three antagonists (NAN-190, p-MPPI and WAY-100635) all produced a statistically significant similar to30% reduction in the number of BrdU-immunoreactive cells in the dentate gyrus. This suggests that 5-HT1A receptor activity is important during naturally occurring cell proliferation in the dentate gyrus, and perhaps neurogenesis, and is one of the many factors involved in its regulation. (C) 2002 Elsevier Science B.V. All rights reserved.