Randomized trials assessing calcium supplementation in healthy children: relationship between industry sponsorship and study outcomes
Randomized trials assessing calcium supplementation in healthy children: relationship between industry sponsorship and study outcomes
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DOI：
10.1017/s136898000900487x
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发表时间：
2009-10-01
影响因子：
3.2
通讯作者：
Bero, Lisa
中科院分区：
文献类型：
--
作者：
Nkansah, Nancy;Nguyen, Thao;Bero, Lisa
目的：探讨行业赞助的钙补充剂研究在健康儿童和研究outcomes.Design之间的关系：电子搜索已发表的随机对照试验（RCT）进行。我们收集了旨在减少偏倚的研究设计特征、结果的统计学显著性、作者的结论和研究的财务赞助的数据。我们使用Fischer的精确检验来检查赞助和研究结果和conclusions.Subjects之间的关联：健康儿童之间的年龄在9和18 years.Results：19项试验符合我们的纳入标准。19项研究中有17项报告了补充剂对骨密度的统计学显着改善。17项研究中有8项的受试者基线每日钙摄入量为800-1300 mg。研究设计特征与研究结果或结论之间无显著相关性。三项研究得到了政府的资助，其中两项（66.7%）的结论是支持额外的补充。16项研究是由行业资助或混合行业资助的，其中13项（81.3%）的结论是支持儿童补充钙。研究赞助和作者的conclusion.Conclusions之间没有显着的关联：大多数RCT评估的影响，钙补充剂在健康儿童的行业资助和支持钙补充剂。在检查研究设计与结果之间的关联时，应考虑钙补充研究中测量的结局的临床意义。需要进一步进行非行业资助的研究，以彻底评估资助对营养研究作者结论的影响。
Objective: To explore the relationship between industry sponsorship of Ca supplementation Studies in healthy children and study outcomes.Design: An electronic search for published randomized controlled trials (RCT) was conducted. We collected data on study design features aimed at reducing bias, statistical significance of results, authors' conclusions and financial sponsorship of study. We used Fischer's exact test to examine associations between sponsorship and study results and conclusions.Subjects: Healthy children between the ages of 9 and 18 years.Results: Nineteen trials met our inclusion criteria. Seventeen Out of nineteen studies reported a statistically significant improvement Of supplementation on bone mineral density. Subjects in eight of the seventeen studies had a baseline daily Ca intake of 800-1300 mg. There was no significant association between Study design features and the results or conclusions of the Studies. Three Studies received government funding, two of which (66.7%) concluded in favour of additional supplementation. Sixteen studies were either industry-funded or had mixed industry funding, thirteen (81.3%) of which had a conclusion Supporting Ca supplementation in children. There was no significant association between Study sponsorship and authors' conclusions.Conclusions: The majority of RCT assessing the effects of Ca supplementation in healthy children are industry-funded and support Ca supplementation. The clinical significance of the Outcomes measured in Ca supplementation studies should be considered when examining associations between Study design and results. Further non-industry funded research is needed to thoroughly assess the impact of funding on authors' Conclusions in nutrition research.