Late preconditioning in rat retina:: involvement of adenosine and ATP-sensitive K+ channel
Late preconditioning in rat retina:: involvement of adenosine and ATP-sensitive K+ channel
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DOI：
10.1016/s0014-2999(01)00938-4
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发表时间：
2001-04-20
影响因子：
5
通讯作者：
Ishii, K
中科院分区：
文献类型：
--
作者：
Sakamoto, K;Kuwagata, M;Ishii, K
目的：探讨腺苷受体的兴奋和ATP敏感性K(+)通道的开放是否参与晚期预适应对大鼠视网膜的保护作用？大鼠视网膜缺血60min。缺血前2 4h给予缺血5min，再给予60min，即可实现缺血预适应。非预适应组大鼠脑缺血60min后7d，神经节细胞层细胞丢失，内丛、内核层变薄。缺血预适应可完全阻止视网膜组织损伤，8-苯茶碱或5-羟基癸酸可降低缺血预适应的保护作用。因此，腺苷受体的兴奋和ATP敏感性K(+)通道的开放可能参与了晚期视网膜预适应的组织保护机制。(C)2001年，爱思唯尔科学公司出版。
To determine whether stimulation of adenosine receptors and opening of ATP-sensitive K(+) channels were involved in the protective effect of late preconditioning in the rat retina? rats were subjected to 60 min of retinal ischemia? and ischemic preconditioning was achieved by applying 5 min of ischemia 24 h before 60 min of ischemia. In non-preconditioned rats, cell loss in the ganglion cell layer and thinning of the inner plexiform and inner nuclear layer were observed 7 days after 60 min of ischemia. Ischemic preconditioning completely prevented the retinal tissue damage and 8-phenyltheophylline or 5-hydroxydecanoate reduced the protective effect of ischemic preconditioning. Therefore, stimulation of adenosine receptors and opening of ATP-sensitive K(+) channels might be involved in the mechanism of histological protection by late preconditioning in the retina. (C) 2001 Published by Elsevier Science B.V.