Toward a cancer-specific diet
Toward a cancer-specific diet
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DOI：
10.1016/j.clnu.2015.01.013
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发表时间：
2016-10-01
影响因子：
6.3
通讯作者：
Zupec-Kania, Beth
中科院分区：
文献类型：
--
作者：
Bozzetti, Federico;Zupec-Kania, Beth
背景和目标：众所周知，癌细胞的能量代谢主要依赖于无氧糖酵解，这促使许多研究人员试图通过热量限制计划来减少实验性肿瘤的恶性细胞生长。最近，这种方法也被提议用于癌症患者。与此同时，研究表明，热量限制对肿瘤生长的影响是通过酮体对线粒体功能缺陷的癌细胞的毒性作用介导的，而这些底物被正常细胞充分利用。方法：本综述分析了关于经历一段时间的饥饿或正常饮食的患者的肿瘤生长的主要可用数据。人工营养以及最近的方法，通过特殊的normocaloric生酮饮食，这是很好地利用癌症患者，而可能是不利的cancercell.Results：尽管缺乏数据，它似乎是通过热量限制/营养支持的肿瘤生长的调制是unlikely在人类有几个原因：不同的肿瘤细胞的生长速度和不同的肿瘤/宿主尸体的比例和治疗的持续时间之间的肿瘤荷瘤动物和patients.Conclusion：有一个很大的共识，在文献中，保持正常的体重和保持瘦体重，通过足够的营养是有益的癌症患者。通过生酮饮食的营养方法可能对癌细胞有毒，同时被患者很好地利用和耐受，在未来似乎很有希望。(C)2015 Elsevier Ltd和欧洲临床营养与代谢学会。All rights reserved.
Background & aims: It is widely acknowledged that the energy metabolism of cancer cells mainly relies on anaerobic glycolysis and this has prompted many researchers to try to reduce the malignant cells growth of experimental tumours through a programme of calorie restriction. Recently this approach has been proposed also to cancer patients. In the meantime it was demonstrated that the effects of calorie restriction on tumour growth are mediated through the toxic effect of ketone bodies on cancer cells which have a defective mitochondrial function, while these substrates are well-utilized by the normal cells.Methods: This review analyzes the main available data regarding the tumour growth in patients undergoing a period of starvation or of normal/artificial nutrition as well as the recent approach through special normocaloric ketogenic diets which are well utilized by cancer patients while may be unfavourable for cancer cells.Results: Despite the paucity of data it appears that modulation of tumour growth by the calorie restriction/nutritional support is unlikekly in humans for several reasons: the different tumour cells growth rate and different tumour/host carcass ratio and duration of treatment, between tumour-bearing animals and patients.Conclusion: There is a large consensus in literature that maintaining a normal body weight and preserving the lean body mass through an adequate nutrition is beneficial in cancer patients. The nutritional approach through a ketogenic diet which may be toxic for the cancer cells while is well utilized and tolerated by the patient seems promising in a next future. (C) 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.