Antiplasmodial and antioxidant isofuranonaphthoquinones from the roots of Bulbine capitata

Antiplasmodial and antioxidant isofuranonaphthoquinones from the roots of Bulbine capitata
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DOI:
10.1055/s-2001-14329
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发表时间:
2001-06-01
期刊:
影响因子:
2.7
通讯作者:
Davis, TME
Davis, TME
中科院分区:
医学3区
文献类型:
--
作者:
Bezabih, M;Abegaz, BM;Davis, TME

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The roots of B. capitata yielded the new compounds 5,8-dihydroxy-1 -tigloylmethylnaphtho[2,3-c]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-c]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-c]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10'-chrysophanol bianthrone, 8-hydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione, 5,8-dihydroxy-1-methylnaphtho[2.3-c]furan-4,9-dione, 5,8-dihydroxy-1-hydroxymethylnaphtho[2,3-c]furan-4,9-dione, and 8-hydroxy-5-methoxy-1-methylnaphtho[2,3-c]furan-4,9-dione, or 5-hydroxy-8-methoxy-1-methylnaphtho[2.3-c]furan-4,9-dione. The new as well as the known isofuranonaphthoquinones showed antioxidant and weak antiplasmodial activities.