Postdischarge medication compliance of inpatients converted from an oral to a depot neuroleptic regimen.
Postdischarge medication compliance of inpatients converted from an oral to a depot neuroleptic regimen.
复制标题
住院患者出院后的用药依从性从口服抗精神病药方案转为长效抗精神病药方案。
DOI：
10.1176/ps.46.10.1049
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Frances,A
中科院分区：
文献类型：
--
作者：
Weiden,P;Rapkin,B;Zygmunt,A;Mott,T;Goldman,D;Frances,A
ESTA初步研究评估门诊药物治疗依从性的影响，从口服转换住院精神分裂症患者的长效抗精神病药物medication.MethodsSubjects由93名抗精神病药物反应住院精神分裂症患者从三个纽约市医院的一部分，为期一年的前瞻性纵向研究的药物治疗依从性。40例患者在住院期间转为长效精神抑制药物治疗;其他53例仍口服药物。症状，副作用，和两组的服药依从性进行了比较，在1，6，和12个月postdischarge.ResultsInpatients转换为贮库型药物治疗有显着更好的遵守在一个月postdischarge。人口统计学特征、症状、医院地点和基线对药物的态度的差异不能解释这一发现。最初的积极影响的依从性减弱，并没有显着的组间差异，发现在6个月和12个月postdischarge.ConclusionsConversion到贮库药物治疗出院前可能会促进药物治疗的依从性过渡到门诊治疗，但需要其他干预措施，以维持随着时间的推移。
ObjectiveThis preliminary study assessed the effects on outpatient medication compliance of converting inpatients with schizophrenia from oral to depot neuroleptic medication.MethodsSubjects consisted of 93 neuroleptic-responsive inpatients with schizophrenia from three New York City hospitals who were part of a one-year prospective longitudinal study of medication compliance. Forty patients were converted to depot neuroleptic medication while hospitalized; the other 53 remained on oral medication. Symptoms, side effects, and medication compliance of the two groups were compared at one, six, and 12 months postdischarge.ResultsInpatients converted to depot medication had significantly better compliance at one month postdischarge. Differences in demographic characteristics, symptoms, hospital site, and baseline attitudes toward medication did not account for this finding. The initial positive effect on compliance waned, and no significant between-group differences in compliance were found at six and 12 months postdischarge.ConclusionsConversion to depot medication before hospital discharge may facilitate medication compliance during transition to outpatient treatment, but other interventions are needed to maintain compliance over time.