Co-infection of SARS-COV-2 and Influenza A Virus: A Case Series and Fast Review.
Co-infection of SARS-COV-2 and Influenza A Virus: A Case Series and Fast Review.
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DOI：
10.1007/s11596-021-2317-2
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发表时间：
2021-03
影响因子：
2.4
通讯作者：
Zhou Q
中科院分区：
文献类型：
--
作者：
Xiang X;Wang ZH;Ye LL;He XL;Wei XS;Ma YL;Li H;Chen L;Wang XR;Zhou Q
2019 年冠状病毒病（COVID-19）发生在流感季节，已成为全球大流行病。本研究旨在检测严重急性呼吸综合征冠状病毒2（SARS-CoV-2）与甲型流感病毒（IAV）的合并感染情况，试图为合并感染患者的抗病毒干预提供线索。我们描述了在中国武汉协和医院接受治疗的两名同时感染 SARS-CoV-2 和 IAV 的患者。此外，我们在 PubMed、Web of Science 和 CNKI（2020 年 1 月 1 日至 11 月 1 日）上以以下关键词组合进行了综述：“COVID-19、SARS-COV-2、甲型流感和合并感染”。共有 28 名合并感染患者参与了分析。 28例患者中，中位年龄为54.5岁（IQR，34.25-67.5），其中14例（50.0%）为重型。最常见的症状是发烧（85.71%）、咳嗽（82.14%）和呼吸困难（60.71%）。 16 名患者入院时出现淋巴细胞减少，23 名患者出现异常放射学变化。从症状出现到入院的中位时间为 4 天（IQR，3-6），中位住院时间为 14 天（IQR，8.5-16.75）。总之，SARS-COV-2和IAV合并感染的患者在症状和放射学图像上与单独感染SARS-COV-2的患者相似。与单独感染 SARS-COV-2 的患者相比，SARS-COV-2 与 IAV 合并感染可能会导致更严重的临床状况，但住院时间不会更长。
Coronavirus disease 2019 (COVID-19) occurs in the influenza season and has become a global pandemic. The present study aimed to examine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection with influenza A virus (IAV) in an attempt to provide clues for the antiviral interventions of co-infected patients. We described two patients who were co-infected with SARS-CoV-2 and IAV treated at Wuhan Union Hospital, China. In addition, we performed a review in PubMed, Web of Science and CNKI (from January 1 up to November 1, 2020) with combinations of the following key words: “COVID-19, SARS-COV-2, influenza A and co-infection”. A total of 28 co-infected patients were enrolled in the analysis. Of the 28 patients, the median age was 54.5 years (IQR, 34.25–67.5) and 14 cases (50.0%) were classified as severe types. The most common symptoms were fever (85.71%), cough (82.14%) and dyspnea (60.71%). Sixteen patients had lymphocytopenia on admission and 23 patients exhibited abnormal radiological changes. The median time from symptom onset to hospital admission was 4 days (IQR, 3–6), and the median time of hospital stay was 14 days (IQR, 8.5–16.75). In conclusion, patients with SARS-COV-2 and IAV co-infection were similar to those infected with SARS-COV-2 alone in symptoms and radiological images. SARS-COV-2 co-infection with IAV could lead to more severe clinical condition but did not experience longer hospital stay compared with patients infected with SARS-COV-2 alone.
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