Dietary patterns and colorectal adenomas in Japanese men - The self-defense forces health study
Dietary patterns and colorectal adenomas in Japanese men - The self-defense forces health study
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DOI：
10.1093/aje/kwi049
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发表时间：
2005-02-15
影响因子：
5
通讯作者：
Kono, S
中科院分区：
文献类型：
--
作者：
Mizoue, T;Yamaji, T;Kono, S
在亚洲人群中，饮食模式在结直肠癌发生中的作用尚不清楚。利用1999-2002年的数据，作者调查了1341名接受全结肠镜检查的日本男性饮食模式与结直肠腺瘤之间的关系。在结肠镜检查前，通过74项食物频率调查问卷获得饮食信息。因子分析产生3种饮食模式：1)高乳制品、高果蔬、高淀粉、低酒精模式；2)“动物性食品”模式；3)日本模式。采用Logistic回归分析来估计患结直肠腺瘤的优势比，并校正了潜在的混杂变量，包括体重指数、吸烟、饮酒和闲暇时间的体育活动。高乳制品、高水果和蔬菜、高淀粉、低酒精的模式存在显著的负相关；第二、三、四分位数的比值比分别为0.97（95%置信区间：0.70、1.36）、0.71（95%置信区间：0.50、1.01）和0.62(95%置信区间：0.43、0.90)，与最低的比值比（p趋势= 0.003）相比。在较大的腺瘤或结直肠的每个亚区也观察到类似的关联。日本和“动物性食物”模式与结直肠腺瘤的关系不明显。多吃乳制品、水果和蔬菜以及低酒精摄入量的饮食模式可能与降低结直肠腺瘤的风险有关。
The role of dietary patterns in colorectal carcinogenesis remains unclear in Asian populations. Using 1999-2002 data, the authors investigated the association between dietary patterns and colorectal adenomas in 1,341 Japanese men who underwent total colonoscopy. Information about diet was obtained using a 74-item food frequency questionnaire prior to the colonoscopy. Three dietary patterns were generated by factor analysis: 1) a high-dairy, high-fruit and -vegetable, high-starch, low-alcohol pattern; 2) an "animal food" pattern; and 3) a Japanese pattern. Logistic regression analysis was used to estimate the odds ratio of having colorectal adenomas with the adjustment for potential confounding variables including body mass index, smoking, alcohol, and leisure-time physical activities. A significant inverse association was found for the high-dairy, high-fruit and -vegetable, high-starch, low-alcohol pattern; the odds ratios for the second, third, and fourth quartiles were 0.97 (95% confidence interval: 0.70, 1.36), 0.71 (95% confidence interval: 0.50, 1.01), and 0.62 (95% confidence interval: 0.43, 0.90), respectively, compared with the lowest (P-trend = 0.003). Similar associations were observed for larger adenomas or for each subsite of the colorectum. The Japanese and "animal food" patterns were not clearly associated with colorectal adenomas. A dietary pattern including greater consumption of dairy products and fruits and vegetables with low alcohol consumption may be associated with decreased risk of colorectal adenomas.