Integrin activation takes shape.
Integrin activation takes shape.
复制标题
整合素激活成形。
DOI：
10.1083/jcb.200206011
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发表时间：
2002-09-02
影响因子：
7.8
通讯作者：
Ginsberg, M H
中科院分区：
文献类型：
--
作者：
Liddington, R C;Ginsberg, M H
整合素是细胞表面粘附受体，对多细胞动物的发育和功能至关重要。在这里，我们总结了最近的研究结果的调节整合素的亲和力配体（激活），细胞调节整合素功能的一种机制。重点是整合素激活的结构基础，整合素亲和力调节的细胞质结构域的作用，以及激活信号从整合素细胞质结构域传播到细胞外配体结合结构域的潜在机制。
Integrins are cell surface adhesion receptors that are essential for the development and function of multicellular animals. Here we summarize recent findings on the regulation of integrin affinity for ligand (activation), one mechanism by which cells modulate integrin function. The focus is on the structural basis of integrin activation, the role of the cytoplasmic domain in integrin affinity regulation, and potential mechanisms by which activation signals are propagated from integrin cytoplasmic domains to the extracellular ligand-binding domain.