A Prospective Cohort of Alcohol Use and Alcohol-related Problems Before and After Metabolic and Bariatric Surgery in Adolescents.
A Prospective Cohort of Alcohol Use and Alcohol-related Problems Before and After Metabolic and Bariatric Surgery in Adolescents.
复制标题
青少年代谢和减肥手术前后饮酒和酒精相关问题的前瞻性队列。
DOI：
10.1097/sla.0000000000005759
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发表时间：
2023
影响因子：
9
通讯作者：
Inge,ThomasH
中科院分区：
文献类型：
--
作者：
White,GretchenE;Boles,RichardE;Courcoulas,AnitaP;Yanovski,SusanZ;Zeller,MegH;Jenkins,ToddM;Inge,ThomasH
目的：描述青少年代谢和减肥手术（MBS）术前和术后长达8年的酒精使用、酒精相关危害和酒精相关问题。背景：成人roux -en- y胃旁路和垂直套管胃切除术后酒精使用和酒精使用障碍（AUD）的风险增加。然而，缺乏接受MBS的青少年的数据。方法：该研究纳入了217名青少年（13-19岁），他们接受了Roux-en-Y胃旁路术或垂直套管胃切除术（2007-2011），并报告术前和术后每年饮酒长达8年。使用累积发生率Kaplan-Meier估计分析酒精使用障碍识别测试-消费（AUDIT-C）得分升高的时间、酒精相关危害和酒精相关问题。结果：术前中位年龄17岁；体重指数中位数为51 kg/ m2。术后饮酒频率和每日平均饮酒量增加（术后6个月2%饮酒2-4次/月，术后8年为24%，P< 0.001；术后6个月2%饮酒≥3次/月，术后8年为35%，P< 0.001）。术后第8年发生的审计- c评分升高、酒精相关伤害和酒精相关问题的累积发生率分别为45%（95% CI: 37-53）、43%（95% CI: 36-51）和47%（95% CI: 40-55）。结论：在青少年时期接受MBS的患者中，近一半的人在MBS后8年的AUD、酒精相关伤害症状或酒精相关问题筛查呈阳性，突出了青少年MBS后酒精使用和AUD的风险。AUD的评估和治疗应纳入MBS青少年的常规长期护理。
Objective:To describe alcohol use, alcohol-related harm, and alcohol-related problems preoperatively and up to 8 years following metabolic and bariatric surgery (MBS) in adolescents.Background:Risk for alcohol use and alcohol use disorders (AUD) increases post-Roux-en-Y gastric bypass and vertical sleeve gastrectomy in adults. However, data are lacking in adolescents who undergo MBS.Methods:This study includes 217 adolescents (aged 13–19 y) enrolled in a 5-center prospective cohort study who underwent Roux-en-Y gastric bypass or vertical sleeve gastrectomy (2007–2011) and reported alcohol use preoperatively and annually postoperatively for up to 8 years. Time to elevated Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) score, alcohol-related harm, and alcohol-related problems were analyzed with Kaplan-Meier estimates of cumulative incidence.Results:Preoperatively, the median age was 17 years; the median body mass index was 51 kg/m 2. Alcohol use frequency and average quantity of drinks per drinking day increased postoperatively (2% consumed alcohol 2–4 times/month 6 months versus 24% 8 years postoperatively, P< 0.001; 2% consumed≥ 3 drinks per drinking day 6 months versus 35% 8 years postoperatively, P< 0.001). Cumulative incidence of postoperative onset elevated AUDIT-C score, alcohol-related harm, and alcohol-related problems at year 8 were 45%(95% CI: 37–53), 43%(95% CI: 36–51), and 47%(95% CI: 40–55), respectively.Conclusions:Nearly half of those who underwent MBS as adolescents screened positively for AUD, symptoms of alcohol-related harm, or alcohol-related problems 8 years post-MBS, highlighting the risk for alcohol use and AUD after MBS in adolescents. AUD evaluation and treatment should be integrated into routine long-term care for adolescents undergoing MBS.