HYPERGLUCAGONISM INDUCED BY GLUCOCORTICOID TREATMENT IN MAN
HYPERGLUCAGONISM INDUCED BY GLUCOCORTICOID TREATMENT IN MAN
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DOI：
10.1056/nejm197301182880305
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发表时间：
1973-01-01
影响因子：
158.5
通讯作者：
VALVERDE, I
中科院分区：
文献类型：
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作者：
MARCO, J;CALLE, C;VALVERDE, I
为了进一步阐明糖皮质激素诱导的碳水化合物代谢改变的性质，对正常志愿者在糖皮质激素治疗前后的基础血浆胰高血糖素水平和精氨酸刺激后的血浆胰高血糖素水平进行了研究。在一组 13 人中，口服泼尼松龙（每天 40 毫克，持续四天）后，空腹胰高血糖素水平增加（+ 24 pg/毫升），并对高精氨酸负荷产生胰高血糖素过度反应（10 分钟时+ 133 pg/毫升，20 分钟时+ 80 pg/毫升，30 分钟时+ 51 pg/毫升）伴随着葡萄糖、氨基氮和胰岛素浓度的升高。在另一组 8 人中，口服泼尼松龙（每天 60 毫克，持续三天）后，观察到空腹胰高血糖素水平上升（+ 17 pg/毫升），并且胰高血糖素对低精氨酸负荷的反应更大（+ 68 pg/毫升，10 分钟）。在第三组（每组 5 人）中，静脉注射泼尼松龙（100 毫克）未能改变血浆胰高血糖素值，因此表明其对 α 细胞的影响不是直接的。糖皮质激素诱导的高胰高血糖素血症可能代表这些激素发挥其致糖尿病作用的另一种方式。
To elucidate further the nature of glucocorticoid-induced alteration of carbohydrate metabolism, plasma glucagon levels, both basal and after an arginine stimulus, were studied in normal volunteers before and after glucocorticoid treatment. In one group of 13, after oral administration of prednisolone (40 mg daily, for four days) an increase in fasting glucagon levels (+ 24 pg per milliliter) and a glucagon hyper-response to a high arginine load (+ 133 pg per milliliter at 10 minutes, + 80 pg per milliliter at 20 minutes and + 51 pg per milliliter at 30 minutes) were accompanied by an elevation of glucose, amino nitrogen and insulin concentrations. In another group of eight, after oral administration of prednisolone (60 mg daily for three days) a rise in fasting glucagon levels (+ 17 pg per milliliter) and a greater glucagon response to a low arginine load (+ 68 pg per milliliter at 10 minutes) were observed. In a third group of five, the intravenous injection of prednisolone (100 mg) failed to alter plasma glucagon values, thus suggesting that its effect on the alpha cell is not direct.Glucocorticoid-induced hyperglucagonemia could represent another way in which these hormones exert their diabetogenic effect.