STUDIES ON IMMUNITY TO MEASLES.
STUDIES ON IMMUNITY TO MEASLES.
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麻疹免疫力研究。
DOI：
10.1016/s0022-3476(65)80112-3
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发表时间：
1965
期刊：
影响因子：
--
通讯作者：
S. M. Stone
中科院分区：
文献类型：
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作者：
S. Krugman;J. P. Giles;H. Friedman;S. M. Stone
麻疹免疫研究自1960年以来一直在进行。麻疹病毒初次感染后，第12天出现可检测抗体的证据;第21天至第28天观察到抗体滴度峰值。随后，在大多数情况下，抗体在能够完全抑制麻疹感染的水平上持续至少四年。然而，当抗体下降到最低或检测不到的水平时，接触麻疹病毒后通常会出现无症状感染和加强反应;在这种情况下，第7天可检测到抗体，第12天可观察到抗体水平达到峰值。这些研究证实了麻疹一次发作后终身免疫的观察结果。它们还为麻疹病毒活疫苗接种一次将赋予永久免疫力的预测提供了强有力的支持。
Studies on immunity to measles have been in progress since 1960. Primary infection with measles virus was followed by evidence of detectable antibody by the twelfth day; peak antibody titers were observed by the twenty-first to the twenty-eighth day. Subsequently, in most instances antibody persisted for at least four years at levels capable of completely inhibiting measles infection. However, when antibody declined to minimal or undetectable levels, exposure to measles virus was usually followed by an asymptomatic infection and a booster response; under these circumstances antibody was detectable by the seventh day and peak antibody levels were observed by the twelfth day. These studies confirm the observation that one attack of measles is followed by lifelong immunity. They also provide strong support for the prediction that one inoculation of live measles-virus vaccine will confer permanent immunity.