Associations of IFN-γ rs2430561 T/A, IL28B rs12979860 C/T and ERα rs2077647 T/C polymorphisms with outcomes of hepatitis B virus infection: a meta-analysis.
Associations of IFN-γ rs2430561 T/A, IL28B rs12979860 C/T and ERα rs2077647 T/C polymorphisms with outcomes of hepatitis B virus infection: a meta-analysis.
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DOI：
10.7555/jbr.28.20130162
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发表时间：
2014-11
影响因子：
2.3
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Tang S;Yue M;Wang J;Zhang Y;Yu R;Su J;Peng Z;Wang J
一些研究探讨了干扰素-γ基因rs2430561T/A、IL28B基因rs12979860C/T和ER-α基因rs2077647T/C多态性与乙肝病毒感染结局的关系，但结果存在争议。因此，我们对所有已发表的观察性研究进行了荟萃分析，以解决这一矛盾。在网上数据库中检索文献，并根据检索结果进行系统综述。共纳入24项研究，两组数据以优势比(OR)表示，可信区间(CI)为95%。Rs2430561T等位基因与持续感染风险降低相关(Tvs.A：OR，0.690；95%CI，[0.490，0.971])，而rs2077647T等位基因显著增加持续感染风险(Tvs.C：OR，1.678；95%CI，[1.212，2.323])。RS 2077647 CC可能在保护个体免受乙肝病毒持续感染中发挥作用(TT vs.CC：OR，4.109；95%CI，[2.609，6.473])。此外，携带rs2430561TT型的携带者比携带AA型的携带者更有可能自发清除乙肝病毒(TTvs.AA：OR，0.555；95%CI，[0.359，0.856])。未发现rs12979860C/T多态与乙肝病毒感染结局显著相关。在亚组分析中，结果与总体分析结果相似。然而，rs2077647 TT与TC+CC相比，在亚洲和以医院为基础的人群中观察到显著增加的风险，但不是在总体分析中。干扰素-γ基因rs2430561T/A和ER-α基因rs2077647T/C与乙肝病毒感染结局相关，而IL28B基因rs12979860C/T与乙肝病毒感染无关。
Several studies investigated associations of IFN-γ rs2430561 T/A, IL28B rs12979860 C/T and ERα rs2077647 T/C gene polymorphisms with outcomes of hepatitis B virus (HBV) infection, but the results were controversial. Therefore, we performed a meta-analysis of all published observational studies to address this inconsistency. Literature was searched in online database and a systematic review was conducted based on the search results. A total of 24 studies were included and dichotomous data were presented as odds ratio (OR) with a 95% confidence interval (CI). The rs2430561 T allele was associated with reduced persistent HBV infection risk (T vs. A: OR, 0.690; 95% CI, [0.490, 0.971]), while the rs2077647 T allele significantly increased the risk of persistent HBV infection (T vs. C: OR, 1.678; 95% CI, [1.212, 2.323]). Rs 2077647 CC might play a role in protecting individuals against HBV persistence (TT vs. CC: OR, 4.109; 95% CI, [2.609, 6.473]). Furthermore, carriers of the rs2430561 TT genotype were more likely to clear HBV spontaneously compared with those of the AA genotype (TT vs. AA: OR, 0.555; 95% CI, [0.359, 0.856]). For rs12979860 C/T polymorphism, no significant correlation with HBV infection outcomes was found. In subgroup analyses, the results were similar to those of overall analysis. However, for rs2077647 TT vs. TC+CC, significantly increased risks were observed in the Asian and hospital-based population, but not in the overall analysis. IFN-γ rs2430561 T/A and ERα rs2077647 T/C genetic polymorphisms were associated with outcomes of HBV infection, but no association was found between IL28B rs12979860 C/T and HBV infection.