TRANSCATHETER ARTERIAL CHEMO-EMBOLIZATION OF RENAL-CELL CARCINOMA WITH MICROENCAPSULATED MITOMYCIN-C
TRANSCATHETER ARTERIAL CHEMO-EMBOLIZATION OF RENAL-CELL CARCINOMA WITH MICROENCAPSULATED MITOMYCIN-C
复制标题
DOI：
10.1016/s0022-5347(17)54880-6
复制
发表时间：
1981-01-01
影响因子：
6.6
通讯作者：
TAMAKAWA, Y
中科院分区：
文献类型：
--
作者：
KATO, T;NEMOTO, R;TAMAKAWA, Y
为提高机械动脉栓塞术的抗肿瘤效果，制备了丝裂霉素C乙基纤维素微囊，用于动脉内注射。动脉内注射丝裂霉素C微囊的潜在治疗作用被认为是微栓塞和延长药物作用时间的作用，即化疗栓塞术。33例肾癌患者接受丝裂霉素C微囊加明胶海绵肝动脉化疗栓塞术，10例行非囊化丝裂霉素C加明胶海绵化疗栓塞术。结果表明，丝裂霉素C微囊明显增强了明胶海绵栓塞术的疗效。外周血的生物测定表明，动脉内注射丝裂霉素C微囊与未包裹的丝裂霉素C相比，显著降低了血液中丝裂霉素C的水平，从而降低了血液毒性。丝裂霉素C微囊化疗栓塞术可能是肾癌的一种有效的术前姑息性治疗措施。
Ethylcellulose microcapsules of mitomycin C were prepared for intra-arterial use to enhance the antineoplastic effects of mechanical arterial embolization. The potential therapeutic effects of intra-arterial mitomycin C microcapsules were considered a function of microembolization and prolonged drug action, i.e., chemoembolization. A total of 33 patients with renal cell carcinoma was subjected to transcatheter arterial chemoembolization with mitomycin C microcapsules supplemented with gelatin sponge; 10 patients were subjected to chemoembolization with non-encapsulated mitomycin C and gelatin sponge. Comparative studies on objective tumor decrease, angiographical findings and histological effects between the 2 treated groups indicated that mitomycin C microcapsules definitely enhanced the therapeutic responses to gelatin sponge embolization. Bioassay of the peripheral blood revealed that intra-arterial mitomycin C microcapsules reduced markedly mitomycin C levels in the blood compared to non-encapsulated mitomycin C, leading to a decrease in hematological toxicity. Chemoembolization with mitomycin C microcapsules probably is effective as a preoperative and palliative measure in the treatment of renal cell carcinoma.