The Physical Activity for Total Health (PATH) Study: rationale and design
The Physical Activity for Total Health (PATH) Study: rationale and design
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DOI：
10.1097/00005768-199909000-00012
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发表时间：
1999-09-01
期刊：
影响因子：
--
通讯作者：
Schwartz, R
中科院分区：
文献类型：
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作者：
McTiernan, A;Ulrich, CM;Schwartz, R
目的：体育锻炼与降低乳腺癌风险有关。这种关联的机制可能涉及激素途径。在一项随机对照研究中，体力活动促进整体健康研究正在测试1年中等强度体力活动干预对绝经后妇女内源性性激素水平的影响。方法：年龄55-75岁、不使用性激素、久坐不动、不吸烟、无内分泌相关疾病或癌症、体重指数大于等于25.0的女性（N = 168）符合条件。女性是通过大量的邮件和媒体广告招募的，她们被随机分配到为期1年的中等强度有氧和力量训练项目（受监控的小组锻炼课程加上家庭锻炼）或控制项目（拉伸课程）。结果：基线和研究结束时测定的血清激素包括：总雌酮、总雌二醇、游离雌二醇、生物利用率雌二醇、硫酸雌酮性激素结合球蛋白、白蛋白、睾酮、游离睾酮、雄烯二酮、脱氢表雄酮、硫酸脱氢表雄酮、胰岛素、葡萄糖和甘油三酯。其他结局指标包括：尿2-羟孕酮：16 α -羟孕酮和雌激素代谢物比值（可能与乳腺癌风险相关）、体重、体重指数、总脂肪质量和体脂肪分布（腰：臀围比、DEXA扫描和计算机断层扫描测量的腹部脂肪）。结论：本研究首次探讨了绝经后妇女体力活动水平变化对性激素的影响。它将深入了解体育活动可能与降低乳腺癌风险相关的可能机制。
Purpose: Physical activity has been associated with a decreased risk for breast cancer. Mechanisms For this association may involve hormonal pathways. The Physical Activity for Total Health study is testing the effect of a 1-yr moderate intensity physical activity intervention on the endogenous sex hormone profile of postmenopausal women in a randomized controlled study. Methods: Women (N = 168) who are aged 55-75 yr, not using sex hormones, sedentary, nonsmokers, have no endocrine-related disease or cancer, and with body mass index of 25.0 or greater, are eligible. Women are recruited through mass mailings and media advertising and are randomized to either a 1-yr moderate intensity aerobic and strength training exercise program (monitored group exercise sessions plus home exercise) or a control program (stretching classes). Results: Serum hormones to be assayed at baseline and at the end of the study include: total estrone, total estradiol, free estradiol, percent bioavailable estradiol, estrone sulfate sex hormone binding globulin, albumin, testosterone, free testosterone, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, insulin, glucose, and triglycerides. Other outcome measures include: the ratio of urinary 2-hydroxyestrone:16 alpha-hydroxyestrone lan estrogen metabolite ratio that may be associated with risk for breast cancer), weight, body mass index, total fat mass, and body fat distribution (waist:hip circumference ratio, DEXA scan, and abdominal fat measured by computed tomography). Conclusion: This study is the first to examine the effect of change in physical activity level on sex hormones in postmenopausal women. It will provide insight into possible mechanisms through which physical activity might be associated with reduced risk of breast cancer.