The Etiology and management of radiotherapy-induced fatigue.
The Etiology and management of radiotherapy-induced fatigue.
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DOI：
10.1080/23809000.2016.1191948
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Saligan, Leorey N
中科院分区：
文献类型：
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作者：
Hsiao, Chao-Pin;Daly, Barbara;Saligan, Leorey N
疲劳是伴随放射治疗的最常见的副作用之一，但可以说是最不了解的。放射治疗诱发的疲劳（RIF）是癌症治疗相关疲劳的一种临床亚型。它被描述为随着时间的推移持续存在的普遍的主观疲劳感，干扰日常生活活动，并且不能通过充分的休息或睡眠来缓解。RIF是局部放射治疗癌症患者的早期副作用之一，且持续时间较长。虽然疲劳的潜在机制已经在几种疾病条件下进行了研究，但RIF的病因，机制和风险因素仍然难以捉摸，并且这种症状仍然管理不善。本文的目的是回顾和讨论最近的文章，定义，提出的生物学基础和机制，以解释RIF的病理生物学，以及文章提出的干预措施，以管理RIF。了解RIF的机制可以描述有希望的途径，以确定风险个体，并确定潜在的治疗靶点，以减轻和预防RIF使用多模式，多学科的方法。
Fatigue is one of the most common side-effects accompanying radiotherapy, but arguably the least understood. Radiotherapy-induced fatigue (RIF) is a clinical subtype of cancer treatment-related fatigue. It is described as a pervasive, subjective sense of tiredness persisting over time, interferes with activities of daily living, and is not relieved by adequate rest or sleep. RIF is one of the early side-effects and long-lasting for cancer patients treated with localized radiation. Although the underlying mechanisms of fatigue have been studied in several disease conditions, the etiology, mechanisms, and risk factors of RIF remain elusive, and this symptom remains poorly managed. The purpose of this paper is to review and discuss recent articles that defined, proposed biologic underpinnings and mechanisms to explain the pathobiology of RIF, as well as articles that proposed interventions to manage RIF. Understanding the mechanisms of RIF can describe promising pathways to identify at-risk individuals and identify potential therapeutic targets to alleviate and prevent RIF using a multimodal, multidisciplinary approach.