The role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy.
The role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy.
复制标题
DOI：
10.1002/prca.201300076
复制
发表时间：
2014-04
影响因子：
2
通讯作者：
Hart, Gerald W.
中科院分区：
文献类型：
--
作者：
Semba, Richard D.;Huang, Hu;Lutty, Gerard A.;Van Eyk, Jennifer E.;Hart, Gerald W.
糖尿病视网膜病变是世界范围内导致失明的主要原因。尽管激光和手术治疗，抗血管生成和其他治疗，以及严格的代谢控制，许多患者仍进展为视力障碍和失明。需要对糖尿病视网膜病变的病理生理学有新的认识，以开发新的方法来改进疾病的检测和治疗以及防盲。高血糖和糖尿病导致通过己糖胺生物合成途径的通量增加，进而导致O-连接β-N-乙酰氨基葡萄糖(O-GlcNAc)对蛋白质丝氨酸/苏氨酸残基的翻译后修饰增加。O-GlcN酰化以类似于蛋白质磷酸化的方式参与许多核蛋白和细胞质蛋白的调节。O-GlcNAc信号的改变参与了糖尿病的发病机制，并可能在糖尿病视网膜病变的发病机制中发挥重要作用。本文就己糖胺生物合成途径和O-GlcNAc信号转导途径的生物学研究进行综述，介绍OGlcNAc信号转导途径在糖尿病和糖尿病视网膜病变中作用的现有证据，并探讨O-GlcNAc在糖尿病视网膜病变发病机制中的未来研究方向。
Diabetic retinopathy is a leading cause of blindness worldwide. Despite laser and surgical treatments, anti-angiogenic and other therapies, and strict metabolic control, many patients progress to visual impairment and blindness. New insights are needed into the pathophysiology of diabetic retinopathy in order to develop new methods to improve the detection and treatment of disease and the prevention of blindness. Hyperglycemia and diabetes result in increased flux through the hexosamine biosynthetic pathway, which, in turn, results in increased post-translational modification of Ser/Thr residues of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc). O-GlcNAcylation is involved in regulation of many nuclear and cytoplasmic proteins in a manner similar to protein phosphorylation. Altered O-GlcNAc signaling has been implicated in the pathogenesis of diabetes and may play an important role in the pathogenesis of diabetic retinopathy. The goal of this review is to summarize the biology of the hexosamine biosynthesis pathway and O-GlcNAc signaling, to present the current evidence for the role of OGlcNAc signaling in diabetes and diabetic retinopathy, and to discuss future directions for research on O-GlcNAc in the pathogenesis of diabetic retinopathy.
登录
查看更多内容
DOI：
10.1056/nejmoa1001288
发表时间：
2010-07-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
ACCORD Study Group;ACCORD Eye Study Group;Chew EY;Ambrosius WT;Davis MD;Danis RP;Gangaputra S;Greven CM;Hubbard L;Esser BA;Lovato JF;Perdue LH;Goff DC Jr;Cushman WC;Ginsberg HN;Elam MB;Genuth S;Gerstein HC;Schubart U;Fine LJ
通讯作者：
Fine LJ
影响因子：
3.5
作者：
Costa, G. N.;Vindeirinho, J.;Santos, P. F.
通讯作者：
Santos, P. F.
影响因子：
8.2
作者：
Berner, A. K.;Brouwers, O.;Stitt, A. W.
通讯作者：
Stitt, A. W.
影响因子：
4.8
作者：
Carrillo, Luz D.;Froemming, Joshua A.;Mahal, Lara K.
通讯作者：
Mahal, Lara K.
DOI：
10.1073/pnas.1200425109
发表时间：
2012-05-08
影响因子：
11.1
作者：
Alfaro, Joshua F.;Gong, Cheng-Xin;Smith, Richard D.
通讯作者：
Smith, Richard D.