MULTIPLE, DISTINCT FORMS OF BOVINE AND HUMAN PROTEIN-KINASE-C SUGGEST DIVERSITY IN CELLULAR SIGNALING PATHWAYS
MULTIPLE, DISTINCT FORMS OF BOVINE AND HUMAN PROTEIN-KINASE-C SUGGEST DIVERSITY IN CELLULAR SIGNALING PATHWAYS
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DOI：
10.1126/science.3755548
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发表时间：
1986-08-22
期刊：
影响因子：
56.9
通讯作者：
ULLRICH, A
中科院分区：
文献类型：
--
作者：
COUSSENS, L;PARKER, PJ;ULLRICH, A
在牛、人类和大鼠基因组中发现了一个新的蛋白激酶c相关基因家族。α -、β -和γ -型蛋白激酶序列是高度同源的，包括一个激酶结构域和潜在的钙结合位点，它们含有分散的可变区域。相应的基因位于不同的人类染色体上；北方和南方杂交分析表明，这个基因家族的遗传复杂性可能更大。
A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.