AN ANCIENT DEVELOPMENTAL INDUCTION - HEAT-SHOCK PROTEINS INDUCED IN SPORULATION AND OOGENESIS
AN ANCIENT DEVELOPMENTAL INDUCTION - HEAT-SHOCK PROTEINS INDUCED IN SPORULATION AND OOGENESIS
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DOI：
10.1126/science.3511530
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发表时间：
1986-03-07
期刊：
影响因子：
56.9
通讯作者：
LINDQUIST, S
中科院分区：
文献类型：
--
作者：
KURTZ, S;ROSSI, J;LINDQUIST, S
迄今为止，每一种真核生物和原核生物都能合成少量的热休克蛋白，以应对高温和其他形式的应激。在酿酒酵母的子囊孢子发育过程中观察到一种特殊的热休克基因表达模式：热休克蛋白hsp26和hsp84被强烈诱导，而这些蛋白中最保守的hsp70既不被热休克诱导也不被热休克诱导。相反，诱导了两种与hsp70相关的蛋白。在果蝇的卵发生过程中也出现了惊人相似的表达模式，这表明它可能是真核细胞中最早进化的发育途径之一。
Every eukaryotic and prokaryotic organism tested to date synthesize a small number of heat-shock proteins in response to heat and other forms of stress. A particular pattern of heat-shock gene expression was observed during ascospore development in Saccharomyces: heat-shock proteins hsp26 and hsp84 were strongly induced, whereas hsp70, the most highly conserved of these proteins, was neither induced nor inducible by heat shock. Instead, two proteins related to hsp70 were induced. A strikingly similar pattern of expression occurs during oogenesis in Drosophila, suggesting that it may be one of the earliest developmental pathways to evolve in eukaryotic cells.