Algorithms for mapping of mRNA targets for microRNA
Algorithms for mapping of mRNA targets for microRNA
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DOI：
10.1089/dna.2006.0566
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发表时间：
2007-04-01
影响因子：
3.1
通讯作者：
Sen, Chandan K.
中科院分区：
文献类型：
--
作者：
Ioshikhes, Ilya;Roy, Sashwati;Sen, Chandan K.
microRNAs（miRNAs）作为编码基因翻译的内源性抑制因子参与人类健康和疾病。在miRNA生物学的早期阶段，鉴定miRNA的特异性同源mRNA靶标是重要的。研究miRNAs在疾病过程中的重要性依赖于假设将特定miRNAs与其推定靶基因连接的算法。这种算法的发展代表了生物医学信息学研究的一个热点领域。目前，缺乏将特定的miRNA与其各自的mRNA靶点联系起来的生物学数据是最严重的限制。本文简要回顾了针对特定miRNA的靶点定位的最流行的概念、最先进的算法和原理。讨论了改进现有生物信息学工具的策略和有效的生物学验证方法。
MicroRNAs (miRNAs) are involved in human health and disease as endogenous suppressors of the translation of coding genes. At this early point of time in miRNA biology, it is important to identify specific cognate mRNA targets for miRNA. Investigation of the significance of miRNAs in disease processes relies on algorithms that hypothetically link specific miRNAs to their putative target genes. The development of such algorithms represents a hot area of research in biomedical informatics. Lack of biological data linking specific miRNAs to their respective mRNA targets represents the most serious limitation at this time. This article presents a concise review addressing the most popular concepts underlying state-of-the-art algorithms and principles aimed at target mapping for specific miRNAs. Strategies for improvement of the current bioinformatics tools and effective approaches for biological validation are discussed.