Neurobiology: Resetting the axon's batteries.
Neurobiology: Resetting the axon's batteries.
复制标题
神经生物学：重置轴突的电池。
DOI：
10.1016/j.cub.2021.06.014
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Giger,RomanJ
中科院分区：
文献类型：
--
作者：
Twiss,JefferyL;Kalinski,AshleyL;Sahoo,PabitraK;Costa,IreneDalla;Giger,RomanJ
神经元损伤可引起线粒体损伤，导致能量产生减少、Ca2+储存能力降低和活性氧增加。一项新的研究揭示了一种机制，可以触发先前锚定的线粒体的轴突运输，并通过用功能性线粒体替换受损的线粒体来促进神经保护和轴突再生。
Neuronal injury can cause mitochondrial damage, leading to reduced energy production, decreased Ca2+storage capacity, and increased reactive oxygen species. A new study reveals a mechanism to trigger the axonal transport of previously anchored mitochondria and promote neuroprotection and axon regeneration by replacing damaged with functional mitochondria.