Plasma lipoprotein lipid and Lp[a] changes with substitution of elaidic acid for oleic acid in the diet.
Plasma lipoprotein lipid and Lp[a] changes with substitution of elaidic acid for oleic acid in the diet.
复制标题
随着饮食中反油酸替代油酸，血浆脂蛋白脂质和 Lp[a] 发生变化。
作者：
P. J. Nestel;M. Noakes;Bryan Belling;Rosemary McArthur;Peter M. Clifton;Edward D. Janus;M. Abbey
通过双盲比较四种不同饮食评估了额外饮食反式脂肪酸（7%能量）对血脂的影响：1，富含黄油脂肪（月桂酸-肉豆蔻酸-棕榈酸）; 2，富含油酸; 3，富含反式脂肪酸; 4，富含棕榈酸。总的饮食期为11周，包括正常食物和特定的脂肪补充剂。在27名轻度高胆固醇血症的男性中，总胆固醇和LDL胆固醇在3周富含油酸的饮食中显着降低，在其他三种饮食中相似。对于四种饮食，LDL胆固醇水平以mg/dl计：1，163; 2，151; 3，165; 4，161。高密度脂蛋白胆固醇与棕榈酸丰富的饮食，42毫克/分升，显着高于油酸，38毫克/分升，这反过来又不低于油酸，38毫克/分升。血浆中的反式脂肪酸浓度上升了7倍，但并没有增加低密度脂蛋白的氧化变化的脆弱性。与所有其他试验饮食相比，富含弹性酸的饮食导致Lp[a]水平显著升高。在富油酸期，Lp[a]水平从第一个（“黄油”）期的235 +/- 182（平均值+/- SD）增加到296 +/- 220 U/l（P <0.001），而在棕榈酸期为249 +/- 204（P <0.001），在油酸期（NS）为236 +/- 201。（250字处删节）
The effect of additional dietary trans fatty acids (7% energy) on plasma lipids was assessed in a double-blind comparison of four separate diets: 1, enriched with butter fat (lauric-myristic-palmitic); 2, oleic acid-rich; 3, elaidic acid-rich; 4, palmitic acid-rich. The total dietary period was 11 weeks and comprised normal foods plus specific fat supplements. In 27 mildly hypercholesterolemic men, total and LDL cholesterol were significantly lower during the 3-week oleic acid-rich diet, and were similar during the other three diets. For the four diets LDL cholesterol levels were in mg/dl: 1, 163; 2, 151; 3, 165; 4, 161. HDL cholesterol was significantly higher with the palmitic acid-rich diet, 42 mg/dl, compared with elaidic acid, 38 mg/dl, which in turn was not lower than with oleic acid, 38 mg/dl. Plasma elaidic acid concentration rose seven-fold with the trans fatty acid diet but did not increase the vulnerability of LDL to oxidative change. The elaidic acid-rich diet led to significant elevations in the level of Lp[a] compared to all the other test diets. The Lp[a] level increased to 296 +/- 220 U/l in the elaidic acid-rich period from 235 +/- 182 (mean +/- SD) in the first ("butter") period (P less than 0.001) compared with 249 +/- 204 in the palmitic acid period (P less than 0.001) and 236 +/- 201 in the oleic acid period (NS).(ABSTRACT TRUNCATED AT 250 WORDS)
膳食饱和脂肪酸（12:0、14:0、16:0）对非人类灵长类动物血浆胆固醇和脂蛋白的影响不同。
DOI：
10.1093/ajcn/53.2.491
发表时间：
1991
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Hayes,KC;Pronczuk,A;Lindsey,S;Diersen-Schade,D
通讯作者：
Diersen-Schade,D
短期膳食胆固醇和脂肪对人血浆 Lp[a] 和 LDL 水平的影响。
影响因子：
6.5
作者：
Brown,SA;Morrisett,J;Patsch,JR;Reeves,R;GottoJr,AM;Patsch,W
通讯作者：
Patsch,W