Frontal dopamine D2/3 receptor binding in drug-naive first-episode schizophrenic patients correlates with positive psychotic symptoms and gender
Frontal dopamine D2/3 receptor binding in drug-naive first-episode schizophrenic patients correlates with positive psychotic symptoms and gender
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DOI：
10.1016/j.biopsych.2006.01.010
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发表时间：
2006-09-15
影响因子：
10.6
通讯作者：
Videbaek, Charlotte
中科院分区：
文献类型：
--
作者：
Glenthoj, Birte Y.;Mackeprang, Torben;Videbaek, Charlotte
背景资料：该研究的目的是检查精神分裂症患者的纹外多巴胺D-2/3受体结合和精神病理学，并将结合电位（BP）值与精神病理学联系起来。方法：25名未接受药物治疗的精神分裂症患者和20名健康对照者使用D-2/3受体配体[I-123]epidepride进行单光子发射计算机断层扫描（SPECT）检查。结果：在迄今为止，对纹状体外D-2/3受体的研究中，我们在较大的男性精神分裂症患者组中检测到额叶D-2、D-3 BP值与阳性精神分裂症症状之间的显著相关性，男性（n = 17）患者的额叶BP值高于女性（n = 8）患者，与此相一致的是，女性患者的阳性精神分裂症症状明显较少。患者和对照组之间的血压值无显著差异;然而，患者右侧丘脑的血压显著高于左侧丘脑，而健康受试者中未观察到显著的半球失衡。目前的数据是第一次确认额叶D-2/3受体BP值和男性精神分裂症患者的阳性症状之间的显着相关性。他们是在协议的假设，额叶D-2/3受体活性是显着的积极精神病症状。此外，这些数据支持精神分裂症患者的丘脑半球失衡。
Background: The aim of the study was to examine extrastriatal dopamine D-2/3 receptor binding and psychopathology in schizophrenic patients, and to relate binding potential (BP) values to psychopathology.Methods: Twenty-five drug-naive schizophrenic patients and 20 healthy controls were examined with single-photon emission computerized tomography (SPECT) using the D-2/3-receptor ligand [I-123]epidepride.Results: In the hitherto, laigeststud'yon extrastriatal D-2/3 receptors we detected a significant correlation between frontal D-2,D-3 BP values and positive schizophrenic symptoms in the larger group of male schizophrenic patients, higher frontal BP values in male (n = 17) compared to female (n = 8)patients, and- in accordance with this-signficantly fewer positive schizophrenic symptoms in the female patients. No significant differences in BP values were observed between patients and controls; the patients, however, had significantly higher BP in the right compared to the left thalamus, whereas no significant hemispheric imbalances were observed in the healthy subjects.Conclusions. The present data are the first to confirm a significant correlation between frontal D-2/3 receptor BP values and positive symptoms in male schizophrenic patients. They are in agreement with the hypothesis that frontal D-2/3 receptor activity is significant for positive psychotic symptoms. Additionally, the data support a thalamic hemispheric imbalance in schizophrenia.