Level of maternal IgG anti-group B streptococcus type III antibody correlated with protection of neonates against early-onset disease caused by this pathogen
Level of maternal IgG anti-group B streptococcus type III antibody correlated with protection of neonates against early-onset disease caused by this pathogen
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DOI：
10.1086/422756
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发表时间：
2004-09-01
影响因子：
6.4
通讯作者：
Clemens, JD
中科院分区：
文献类型：
--
作者：
Lin, FYC;Weisman, LE;Clemens, JD
本研究评估了母亲免疫球蛋白（IG）G抗B链球菌（GBS）III型的水平，以保护新生儿免受这种病原体引起的早发性疾病（EOD）。采用酶联免疫吸附试验（ELISA）检测了26例妊娠34周以上的GBS Ⅲ型所致EOD患儿（新生儿）和43例妊娠34周以上的GBS Ⅲ型定殖儿（新生儿未发生EOD）的母血IgG抗GBS Ⅲ型抗体水平。EOD的概率随着母体IgG抗GBS III型水平的增加而降低（P = .01）。与母亲IgG抗GBS III型抗体水平≥ 10 μ g/mL的新生儿相比，母亲IgG抗GBS III型抗体水平≥ 10 μ g/mL的新生儿发生EOD的风险降低了91%，可以预测，母亲IgG抗GBS III型抗体水平≥ 10 μ g/mL的新生儿对该病原体引起的EOD具有显著的保护作用。
The present study estimates the level of maternal immunoglobulin (Ig) G anti-group B streptococcus (GBS) type III required to protect neonates against early-onset disease (EOD) caused by this pathogen. Levels of maternal serum IgG anti-GBS type III, measured by enzyme-linked immunosorbent assay, in 26 case patients ( neonates with EOD caused by GBS type III) and greater than or equal to43 matched control subjects ( neonates colonized by GBS type III who did not develop EOD) of greater than or equal to 34 weeks gestation were compared. The probability of EOD decreased with increasing levels of maternal IgG anti-GBS type III (P = .01). Neonates whose mothers had greater than or equal to10 mug/mL IgG anti-GBS type III had a 91% lower risk for EOD, compared with those whose mothers had levels of = 10 mu g/mL in mothers can be predicted to offer a significant degree of protection against EOD caused by this pathogen.