Transient Biocompatible Polymeric Platforms for Long-Term Controlled Release of Therapeutic Proteins and Vaccines
Transient Biocompatible Polymeric Platforms for Long-Term Controlled Release of Therapeutic Proteins and Vaccines
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DOI：
10.3390/ma9050321
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发表时间：
2016-05-01
期刊：
影响因子：
3.4
通讯作者：
Montazami, Reza
中科院分区：
文献类型：
--
作者：
Acar, Handan;Banerjee, Saikat;Montazami, Reza
具有可控和可编程降解和释放动力学的基于聚合物的互穿网络（IPN）使治疗性蛋白质或疫苗的物理吸附和受控释放具有独特的机会，同时保持其化学和结构完整性。本文介绍了一系列长期可编程的，生物相容的，可生物降解的聚合物基IPN控释平台的材料，一个简单的制备方法，和释放动力学。通过调节和改变IPN平台的化学结构，在30天的时间内控制gp41蛋白的释放动力学。释放后分析证实了整个过程中gp41蛋白的结构保守性。细胞活力测定证实了IPN的生物相容性和无细胞毒性。
Polymer-based interpenetrating networks (IPNs) with controllable and programmable degradation and release kinetics enable unique opportunities for physisorption and controlled release of therapeutic proteins or vaccines while their chemical and structural integrities are conserved. This paper presents materials, a simple preparation method, and release kinetics of a series of long-term programmable, biocompatible, and biodegradable polymer-based IPN controlled release platforms. Release kinetics of the gp41 protein was controlled over a 30-day period via tuning and altering the chemical structure of the IPN platforms. Post-release analysis confirmed structural conservation of the gp41 protein throughout the process. Cell viability assay confirmed biocompatibility and non-cytotoxicity of the IPNs.