Tumor-Derived Vascular Pericytes Anergize Th Cells
Tumor-Derived Vascular Pericytes Anergize Th Cells
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DOI：
10.4049/jimmunol.1300280
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发表时间：
2013-07-15
影响因子：
4.4
通讯作者：
Majumdar, Subrata
中科院分区：
文献类型：
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作者：
Bose, Anamika;Barik, Subhasis;Majumdar, Subrata
肿瘤微环境中的免疫逃避支持恶性生长，也是成功免疫治疗的主要障碍。多种细胞成分和可溶性因子协调破坏保护性免疫应答。尽管基质细胞在肿瘤形成和进展中的实质支持作用是众所周知的，但据我们所知，我们首次证明肿瘤来源的血管周细胞对CD 4（+）T细胞的活化和增殖产生负面影响，并通过G蛋白信号传导5-和IL-6依赖性途径的调节剂促进CD 4（+）CD 44（+）T细胞对Ag的回忆反应无反应性。我们的数据支持肿瘤衍生的周细胞在肿瘤微环境内的免疫逃避范例中的新的特定作用，并表明在成功的免疫治疗癌症的背景下靶向这些细胞群体。
Immune evasion within the tumor microenvironment supports malignant growth and is also a major obstacle for successful immunotherapy. Multiple cellular components and soluble factors coordinate to disrupt protective immune responses. Although stromal cells are well-known for their parenchymal supportive roles in cancer establishment and progression, we demonstrate for the first time, to our knowledge, that tumor-derived vascular pericytes negatively influence CD4(+) T cell activation and proliferation, and promote anergy in recall response to Ag by CD4(+)CD44(+) T cells via regulator of G protein signaling 5- and IL-6-dependent pathways. Our data support a new specific role for tumor-derived pericytes in the immune evasion paradigm within the tumor microenvironment and suggest the targeting of these cell populations in the context of successful immunotherapeutics for the treatment of cancer.