Net uptake of adenine nucleotides in isolated rat liver mitochondria.
Net uptake of adenine nucleotides in isolated rat liver mitochondria.
复制标题
离体大鼠肝线粒体中腺嘌呤核苷酸的净摄取。
DOI：
10.1016/0014-5793(80)80934-3
复制
发表时间：
1980
期刊：
影响因子：
3.5
通讯作者：
Aprille,JR
中科院分区：
文献类型：
--
作者：
Asimakis,GK;Aprille,JR
大鼠肝线粒体腺嘌呤核苷酸含量在围产期发育过程中增加[1 -3]。由于整个肝脏的总腺嘌呤核苷酸（ATP+ ADP+ AMP）在围产期期间保持恒定[2]，因此推断腺嘌呤核苷酸库从细胞溶质转移到线粒体区室。据报道，在成年大鼠中，胰高血糖素注射可诱导肝脏线粒体中总腺嘌呤核苷酸含量增加60-65%[4，5]。我们在体外去除了内源性腺嘌呤核苷酸的肝线粒体中腺嘌呤核苷酸的净摄取[6]。目的是进一步研究线粒体从线粒体外空间准确提取腺嘌呤核苷酸的可能机制。
The adenine nucleotide content of rat liver mitochondria increases during perinatal development [l-3]. Since the total adenine nucleotides (ATP+ ADP+ AMP) of the whole liver remain constant during the perinatal period [2], a shifting of the adenine nucleotide pool from the cytosolic to the mitochondrial compartment is inferred. In adult rats glucagon injection has been reported to induce a 60-65% increase in the total adenine nucleotide content of liver mitochondria [4, 5]. We deported the net uptake of adenine nucleotides in liver mitochondria that had been depleted of endogenous adenine nucleotides in vitro [6]. The objective of this was to examine further a possible mechanism by which mitochondria can accurate adenine nucleotides from the extramitochondrial space.