Cytotoxic Chaetoglobosins from the Endophyte Chaetomium globosum
Cytotoxic Chaetoglobosins from the Endophyte Chaetomium globosum
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来自内生菌球毛壳菌的细胞毒性毛球蛋白
DOI：
10.1055/s-0030-1249936
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发表时间：
2010-11-01
期刊：
影响因子：
2.7
通讯作者：
Tan, Ren Xiang
中科院分区：
文献类型：
--
作者：
Zhang, Jie;Ge, Hui Ming;Tan, Ren Xiang
从球毛壳菌（Chaetomium globosum）IFB-E041固体培养物的乙酸乙酯提取物中分离得到两个新的生物碱球毛壳菌素V（1）和W（2），以及6个已知的同系物3-8。通过波谱方法主要包括1D和2D NMR技术进行了结构鉴定。球毛藻素W（2）的独特之处在于其具有通过C-3和C-6之间的氧桥形成的氧杂环戊烷环。分离的真菌代谢产物对四种人癌细胞系（KB、K562、MCF-7和HepG 2）表现出中等的细胞毒活性，其IC 50值在18-30 μ g/mL的范围内。
Two new alkaloids chaetoglobosins V (1) and W (2), together with the six known congeners 3-8, were isolated through bioassay-guided fractionations from the EtOAc extract of a solid culture of Chaetomium globosum IFB-E041. The structures were elucidated by spectroscopic methods including mainly 1D and 2D NMR techniques. Chaetoglobosin W(2) was unique in its possession of an oxolane ring formed via an oxygen bridge between C-3 and C-6. The isolated fungal metabolites exhibited moderate cytotoxic activities against four human cancer cell lines (KB, K562, MCF-7, and HepG2) with their IC50 values in a range of 18-30 mu g/mL.