Fearfulness and sex in F2 Roman rats:: males display more fear though both sexes share the same fearfulness traits
Fearfulness and sex in F2 Roman rats:: males display more fear though both sexes share the same fearfulness traits
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DOI：
10.1016/s0031-9384(03)00043-x
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发表时间：
2003-04-01
影响因子：
2.9
通讯作者：
Tobeña, A
中科院分区：
文献类型：
--
作者：
Aguilar, R;Gil, L;Tobeña, A
研究人员对来自近亲繁殖的罗马高回避型和低回避型大鼠的2代大鼠（雌雄各约400只）的性别差异模式进行了研究，这些大鼠的恐惧程度和大脑功能不同。我们通过对一系列新/威胁性测试(开放场地（of）加迷宫（PM）、孔板（HB）、活动（a)和声惊吓反射（ASR））以及习得恐惧范式（经典恐惧条件反射（CFC）和毽子回避条件反射（SAC））的反应来获得测量结果。结果表明，几乎所有评估的行为都符合雄性大鼠比雌性大鼠更害怕的单向性别效应模式：雄性大鼠在of、PM、HB、ASR和CFC中比雌性大鼠排便更多；在OF， PM， A和SAC中走动较少；PM和HB表现出更多的自我修饰；探索了PM张开的手臂和HB less的洞；显示ASR增强；在SAC任务中表现较差。我们对每个性别进行了两个因素分析，结果表明，总的来说，他们有一个共同的三因素结构：一个由SAC和CFC反应组成的习得性恐惧因素，一个对高度/开放空间的恐惧因素，在PM时张开手臂行为的负荷最高，以及一个情绪反应因素，主要分为排便、行走和自我梳理。这些结果表明，在近亲繁殖但基因异质的种群中，两性的恐惧行为的基本成分是相似的。(C) 2003爱思唯尔科学有限公司版权所有。
The pattern of sex differences in a large sample (about 400 for each sex) of F2-generation rats, derived from inbred Roman high- and low-avoidance strains differing in fearfulness and brain functioning, was investigated. We obtained measures from responses to a battery of novel/threatening tests [open field (OF), plus maze (PM), hole board (HB), activity (A), and acoustic startle reflex (ASR)] as well as learned fear paradigms [classical fear conditioning (CFC) and shuttlebox avoidance conditioning (SAC)]. The results showed that almost all behaviors assessed fit with a pattern of unidirectional sex effects characterized by male rats as being more fearful than females: males defecated more than females in the OF, PM, HB, ASR, and CFC; ambulated less in the OF, PM, A, and SAC; showed more self-grooming in PM and HB; explored the open arms of the PM and the holes of the HB less; displayed enhanced ASR; and showed poorer performance in the SAC task. We applied two factor analyses to each sex showing that, in general, they shared a common three-factor structure: a Learned Fear Factor comprising SAC and CFC responding, a Fear of Heights/Open Spaces Factor with the highest loadings for open arm behavior in the PM, and an Emotional Reactivity Factor, mainly grouping defecations, ambulation, and self-grooming. These results indicate that the essential components of fearful behavior are similar for both sexes in an inbred but genetically heterogeneous population. (C) 2003 Elsevier Science Inc. All rights reserved.