Micropeptides Encoded in Transcripts Previously Identified as Long Noncoding RNAs: A New Chapter in Transcriptomics and Proteomics.
Micropeptides Encoded in Transcripts Previously Identified as Long Noncoding RNAs: A New Chapter in Transcriptomics and Proteomics.
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DOI：
10.3389/fgene.2018.00144
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发表时间：
2018
影响因子：
3.7
通讯作者：
Akimitsu N
中科院分区：
文献类型：
--
作者：
Yeasmin F;Yada T;Akimitsu N
利用基于组学的技术进行综合分析，在转录本中发现了大量具有蛋白质编码能力的短开放阅读框（sorf），这些转录本以前被鉴定为长非编码rna （lncRNAs）或未知功能转录本（tuf）。sorf以前被忽视，因为它们的体积小，难以通过生物信息学分析识别。现在有越来越多的证据表明，在不同物种的细胞中存在由sorf产生的潜在功能微肽。最近对其中一些的描述揭示了它们在许多基本生物学过程中的显著不同作用，其中一些也显示出与发病机制的重要关系。因此，最近的工作为探索可能存在于sorf编码的短蛋白中的丰富信息提供了新的见解。本文就蛋白质编码基因sorf中编码的微肽的研究进展及展望作一综述。
Integrative analysis using omics-based technologies results in the identification of a large number of putative short open reading frames (sORFs) with protein-coding capacity within transcripts previously identified as long noncoding RNAs (lncRNAs) or transcripts of unknown function (TUFs). sORFs were previously overlooked because of their diminutive size and the difficulty of identification by bioinformatics analyses. There is now growing evidence of the existence of potentially functional micropeptides produced from sORFs within cells of diverse species. Recent characterization of a few of these revealed their significant divergent roles in many fundamental biological processes, where some also show important relationships with pathogenesis. Recent works therefore provide new insights for exploring the wealth of information that may lie within sORF-encoded short proteins. Here, we summarize the current progress and view of micropeptides encoded in sORFs of protein-coding genes.