Direct and metal-free oxidative amination of sp(3) C-H bonds for the construction of 2-hetaryl-quinazolin-4(3H)-ones
Direct and metal-free oxidative amination of sp(3) C-H bonds for the construction of 2-hetaryl-quinazolin-4(3H)-ones
复制标题
sp(3) C-H 键的直接无金属氧化胺化用于构建 2-杂芳基-喹唑啉-4(3H)-酮
DOI：
10.1039/c6qo00231e
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发表时间：
2016
影响因子：
5.4
通讯作者：
Ma Chen
中科院分区：
文献类型：
--
作者：
Liu Huanhuan;Zhai Tianran;Ding Shiteng;Hou Yalei;Zhang Xiangyu;Feng Lei;Ma Chen
介绍了在无过渡金属条件下，以2-氨基苯酰胺和（2-氮杂基）甲烷为原料合成2-乙基喹唑啉-4(3H)-酮的新方法。该方案具有广泛的底物范围，在温和条件下具有广泛的功能基团耐受性。（2-氮杂aaryl）甲烷氧化为（2-氮杂aaryl）甲醇是该转化的关键步骤。
A new method for the synthesis of 2-hetarylquinazolin-4(3H)-ones from 2-aminobenzamides and (2-azaaryl)methanes under transition metal-free conditions is described. This protocol features a wide substrate scope with a broad range of functional group tolerance under mild conditions. The oxidation of (2-azaaryl)methanes to (2-azaaryl)methanals is proposed as the key step in this transformation.