Individual differences in subjective and objective alertness during sleep deprivation are stable and unrelated
Individual differences in subjective and objective alertness during sleep deprivation are stable and unrelated
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DOI：
10.1152/ajpregu.00197.2002
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发表时间：
2003-02-01
影响因子：
2.8
通讯作者：
Van Cauter, E
中科院分区：
文献类型：
--
作者：
Leproult, R;Colecchia, EF;Van Cauter, E
本研究探讨了个人的再现性的主观，客观和EEG的警觉性措施在27小时的连续清醒的变化，并分析了它们之间的相互关系。8名受试者在类似的常规条件下进行了两次研究。以每小时的时间间隔管理量表和性能任务，以定义主观和客观警觉性的时间变化。每2 h记录一次清醒脑电图，睁眼2 min记录一次，闭眼2 min记录一次。测量血浆葡萄糖和褪黑激素水平，以估计脑葡萄糖利用率和个人的昼夜节律时相，分别。主观警觉性和性能缺陷的下降被认为是高度可重复的一个给定的个人。值得注意的是，主观和客观警觉性的损害之间没有关系。随着清醒持续时间的增加，闭眼时的EEG活动在δ范围内增加，在α范围内减少，但这些变化的幅度也是无关的。这些发现表明，睡眠剥夺对控制主观和客观警觉性的大脑机制具有高度可重复但独立的影响。
This study examines the individual reproducibility of alterations of subjective, objective, and EEG measures of alertness during 27 h of continuous wakefulness and analyzes their interrelationships. Eight subjects were studied twice under similar constant-routine conditions. Scales and performance tasks were administered at hourly intervals to define temporal changes in subjective and objective alertness. The wake EEG was recorded every 2 h, 2 min with eyes open and 2 min with eyes closed. Plasma glucose and melatonin levels were measured to estimate brain glucose utilization and individual circadian phase, respectively. Decrements of subjective alertness and performance deficits were found to be highly reproducible for a given individual. Remarkably, there was no relationship between the impairments of subjective and objective alertness. With increased duration of wakefulness, EEG activity with eyes closed increased in the delta range and decreased in the alpha range, but the magnitudes of these changes were also unrelated. These findings indicate that sleep deprivation has highly reproducible, but independent, effects on brain mechanisms controlling subjective and objective alertness.