Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2 II. Structure elucidation
Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2 II. Structure elucidation
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Xanthoradones，亚胺培南对抗耐甲氧西林金黄色葡萄球菌活性的新增强剂，由青霉 FKI-3765-2 II 产生。
DOI：
10.1038/ja.2009.61
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
H. Tomoda
中科院分区：
文献类型：
--
作者：
H. Yamazaki;S. Ōmura;H. Tomoda
真菌菌株FKI-3765-2经鉴定为根青霉菌，对耐甲氧西林金黄色葡萄球菌(MRSA)产生亚胺培南活性增强剂。采用溶剂萃取、十八烷基硅烷柱层析和制备高效液相等方法，从产生菌发酵液中分离得到2个新化合物，命名为xanthoradone A和B。Xanthoradone A和B将亚胺培南的MIC值从16μg ml−1分别降至0.060和0.030μg ml−1，从而增强了亚胺培南对MRSA的抗菌活性。
The fungal strain FKI-3765-2, identified as Penicillium radicum, was found to produce potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus (MRSA). Two new compounds, designated xanthoradones A and B, were isolated from the fermentation broth of the producing strain by solvent extraction, octadecyl silyl column chromatography and preparative HPLC. Xanthoradones A and B potentiated imipenem activity against MRSA by decreasing the MIC value of imipenem from 16 μg ml− 1 to 0.060 and 0.030 μg ml− 1, respectively.