Switching Reaction Pathways of Benzo[b]thiophen-3-yllithium and Benzo[b]furan-3-yllithium Based on High-resolution Residence-time and Temperature Control in a Flow Microreactor
Switching Reaction Pathways of Benzo[b]thiophen-3-yllithium and Benzo[b]furan-3-yllithium Based on High-resolution Residence-time and Temperature Control in a Flow Microreactor
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DOI：
10.1246/cl.2011.393
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发表时间：
2011-04-05
影响因子：
1.6
通讯作者：
Yoshida, Jun-ichi
中科院分区：
文献类型：
--
作者：
Asai, Tatsuro;Takata, Atsushi;Yoshida, Jun-ichi
在流动微反应器系统中实现了苯并[B]噻吩-3-基锂和苯并[B]呋喃-3-基锂的反应途径控制。通过选择合适的停留时间和温度，可以在开环前与开环后的亲电试剂反应之间任意切换。
Reaction-pathway control of benzo[b]thiophen-3-yllithium and benzo[b]furan-3-yllithium was accomplished in flow microreactor systems. We could switch between the reaction with an electrophile before ring-opening and that after ring-opening at will by choosing an appropriate residence-time and temperature.