Effect of resveratrol on fat mobilization
Effect of resveratrol on fat mobilization
复制标题
DOI：
10.1111/j.1749-6632.2010.05845.x
复制
发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Della-Fera, Mary Anne
中科院分区：
文献类型：
--
作者：
Baile, Clifton A.;Yang, Jeong-Yeh;Della-Fera, Mary Anne
较高的身体脂肪水平与许多不良健康状况的发展风险增加有关。植物化学物质是抑制前脂肪细胞分化、刺激脂肪分解和诱导现有脂肪细胞凋亡从而减少脂肪组织质量的潜在试剂。白藜芦醇降低成熟前脂肪细胞的脂肪形成和活力，这些作用不仅通过下调脂肪细胞特异性转录因子和酶，而且通过调节线粒体功能的基因介导。此外，白藜芦醇增加脂肪分解，减少成熟脂肪细胞中的脂肪生成。此外，将白藜芦醇与其他天然产物结合，对脂肪细胞生命周期中的多个分子靶点产生协同作用。单独用白藜芦醇治疗小鼠，可以提高对高脂饮食引起的体重增加的抵抗力。此外，老年卵巢切除大鼠的饮食补充与白藜芦醇和维生素D，槲皮素，染料木素的组合不仅减少体重增加，但也抑制骨质流失。结合几种植物化学物质，包括白藜芦醇，或使用它们作为合成新药的模板，为使用植物化学物质靶向脂肪细胞脂肪生成，凋亡和脂解提供了很大的潜力。
Higher levels of body fat are associated with increased risk for development of numerous adverse health conditions. Phytochemicals are potential agents to inhibit differentiation of preadipocytes, stimulate lipolysis, and induce apoptosis of existing adipocytes, thereby reducing adipose tissue mass. Resveratrol decreased adipogenesis and viability in maturing preadipocytes; these effects were mediated not only through down-regulating adipocyte specific transcription factors and enzymes but also by genes that modulate mitochondrial function. Additionally, resveratrol increased lipolysis and reduced lipogenesis in mature adipocytes. In addition, combining resveratrol with other natural products produced synergistic activities from actions on multiple molecular targets in the adipocyte life cycle. Treatment of mice with resveratrol alone was shown to improve resistance to weight gain caused by a high-fat diet. Moreover, dietary supplementation of aged ovariectomized rats with a combination of resveratrol and vitamin D, quercetin, and genistein not only decreased weight gain but also inhibited bone loss. Combining several phytochemicals, including resveratrol, or using them as templates for synthesizing new drugs, provides a large potential for using phytochemicals to target adipocyte adipogenesis, apoptosis, and lipolysis.