Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study
Altered White Matter Microarchitecture in the Cingulum Bundle in Women With Primary Dysmenorrhea: A Tract-Based Analysis Study
复制标题
原发性痛经女性扣带束白质微结构的改变：基于束的分析研究
DOI：
10.1002/hbm.23670
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发表时间：
2017-09-01
影响因子：
4.8
通讯作者：
Zhang, Ming
中科院分区：
文献类型：
--
作者：
Liu, Jixin;Liu, Hongjuan;Zhang, Ming
原发性痛经（PD）是一种与中枢敏感化和脑功能改变有关的无器质性原因的疼痛性痛经。先前的研究表明，默认模式网络（DMN）在疼痛连接体中的整合作用及其对个体如何感知和应对疼痛障碍的关键贡献。在这里，我们的目的是调查是否扣带束连接枢纽地区的DMN被破坏的年轻女性PD。在41例PD患者和41例匹配的健康对照（HC）在其排卵期获得扩散张量成像。在PD患者的无痛期和疼痛期获得了前列腺素（PGs）的产生。与HC相比，PD患者在无痛期的疼痛强度、焦虑和抑郁评分相似。然而，改变白色物质的属性主要位于后段扣带束观察PD。除了PG与月经痛有关外，还发现PD患者无痛期扣带回束的白色物质性质与月经痛的严重程度之间存在密切关系。本研究提示PD患者的扣带束内白色物质完整性的特征性改变持续到月经期以后。我们推断，改变的解剖连接可能会导致DMN内和/或DMN与其他疼痛相关脑网络之间的通信不太灵活，这可能会导致PD后期患慢性疼痛的中枢易感性。(C)2017年Wiley Periodicals，Inc.
Primary dysmenorrhea (PD), as characterized by painful menstrual cramps without organic causes, is associated with central sensitization and brain function changes. Previous studies showed the integrated role of the default mode network (DMN) in the pain connectome and its key contribution on how an individual perceives and copes with pain disorders. Here, we aimed to investigate whether the cingulum bundle connecting hub regions of the DMN was disrupted in young women with PD. Diffusion tensor imaging was obtained in 41 PD patients and 41 matched healthy controls (HC) during their periovulatory phase. The production of prostaglandins (PGs) was obtained in PD patients during their pain-free and pain phases. As compared with HC, PD patients had similar scores of pain intensity, anxiety, and depression in their pain-free phase. However, altered white matter properties mainly located in the posterior section of the cingulum bundle were observed in PD. Besides PGs being related to menstrual pain, a close relationship was found between the white matter properties of the cingulum bundle during the pain-free phase and the severity of the menstrual pain in PD patients. Our study suggested that PD had trait changes of white matter integrities in the cingulum bundle that persisted beyond the time of menstruation. We inferred that altered anatomical connections may lead to less-flexible communication within the DMN, and/or between the DMN and other pain-related brain networks, which may result in the central susceptibility to develop chronic pain conditions in PD's later life. (C) 2017 Wiley Periodicals, Inc.