Central release of oxytocin, vasopressin and neurophysin by magnocellular neurone depolarization: evidence in slices of guinea pig and rat hypothalamus.
Central release of oxytocin, vasopressin and neurophysin by magnocellular neurone depolarization: evidence in slices of guinea pig and rat hypothalamus.
复制标题
大细胞神经元去极化导致催产素、加压素和神经素的中枢释放：豚鼠和大鼠下丘脑切片的证据。
DOI：
10.1159/000124457
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发表时间：
1986
影响因子：
4.1
通讯作者：
Robinson,IC
中科院分区：
文献类型：
--
作者：
Mason,WT;Hatton,GI;Ho,YW;Chapman,C;Robinson,IC
使用大鼠下丘脑保持在体外的切片，我们研究了神经元活动增加的条件下，催产素和加压素的释放。我们在这里报告，当视上核或室旁核去极化与高K+的解决方案，激素被释放到靠近核的区域。用豚鼠下丘脑进行的类似实验表明，neurophysin也可能与催产素和加压素共同释放。使用乙酰胆碱选择性刺激加压素神经元似乎引起局部加压素而不是催产素释放的增加。这些结果表明，在神经元活动增加的条件下，通常从神经垂体分泌的激素被分泌到下丘脑局部。
Using slices of rat hypothalamus maintained in vitro, we have examined release of oxytocin and vasopressin under conditions of increased neuronal activity. We report here that when the supraoptic or paraventricular nucleus is depolarized with high K+solutions, hormone is released into areas close to the nucleus. Similar experiments with guinea pig hypothalamus suggest that neurophysin may also be co-released with oxytocin and vasopressin. Use of acetylcholine to selectively stimulate vasopressin neurones appears to evoke a rise in local release of vasopressin but not oxytocin. These results suggest that under conditions of increased neuronal activity, hormones normally secreted from the neurohypophysis are secreted locally into the hypothalamus.