Topographic distinction in long-term value signals between presumed dopamine neurons and presumed striatal projection neurons in behaving monkeys
Topographic distinction in long-term value signals between presumed dopamine neurons and presumed striatal projection neurons in behaving monkeys
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DOI：
10.1038/s41598-020-65914-0
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发表时间：
2020-06-02
影响因子：
4.6
通讯作者：
Yamada, Hiroshi
中科院分区：
文献类型：
--
作者：
Enomoto, Kazuki;Matsumoto, Naoyuki;Yamada, Hiroshi
黑质纹状体多巴胺（DA）投射在解剖学上沿背外侧 - 腹内侧轴分布，向纹状体传递长期价值信号，以塑造针对多种未来奖励的行为。本研究检验了根据解剖学文献所预测的，在假定的多巴胺神经元和假定的纹状体投射神经元（相位激活神经元，PANs）活动时是否能观察到长期价值信号的地形组织。我们的结果表明，背外侧中脑的多巴胺神经元在较短时间尺度上编码长期价值信号，而腹内侧中脑的多巴胺神经元在相对较长的时间尺度上编码此类信号。背侧纹状体中PANs的活动在编码长期价值方面更具异质性，尽管在尾状核和壳核之间观察到长期价值信号存在显著差异。这些发现表明，用于长期价值的地形多巴胺信号并非简单地传递到纹状体神经元，这可能是由于其他向纹状体的投射所起的作用。
Nigrostriatal dopamine (DA) projections are anatomically organized along the dorsolateral-ventromedial axis, conveying long-term value signals to the striatum for shaping actions toward multiple future rewards. The present study examines whether the topographic organization of long-term value signals are observed upon activity of presumed DA neurons and presumed striatal projection neurons (phasically active neurons, PANs), as predicted based on anatomical literature. Our results indicate that DA neurons in the dorsolateral midbrain encode long-term value signals on a short timescale, while ventromedial midbrain DA neurons encode such signals on a relatively longer timescale. Activity of the PANs in the dorsal striatum is more heterogeneous for encoding long-term values, although significant differences in long-term value signals were observed between the caudate nucleus and putamen. These findings suggest that topographic DA signals for long-term values are not simply transferred to striatal neurons, possibly due to the contribution of other projections to the striatum.