THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS. II. A CELLULAR BASIS FOR THE DEVELOPMENT OF RESISTANCE WITH AGE.
THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS. II. A CELLULAR BASIS FOR THE DEVELOPMENT OF RESISTANCE WITH AGE.
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DOI：
10.1084/jem.120.3.359
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发表时间：
1964-09-01
期刊：
影响因子：
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通讯作者：
JOHNSON RT
中科院分区：
文献类型：
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作者：
JOHNSON RT
用荧光抗体染色法研究了小鼠对疱疹病毒脑炎随年龄增长的抵抗力。成年小鼠对脑内接种仍然敏感，中枢神经系统的感染与未成熟小鼠相同。随着成熟，免疫接种的病毒在神经外的传播形成了“屏障”，传播的限制似乎与腹膜和组织巨噬细胞的感染一致。在体外，哺乳和成年小鼠巨噬细胞同样容易感染。然而，哺乳小鼠巨噬细胞会感染与其接触的其他细胞，而感染的成年小鼠巨噬细胞则不会。研究未能揭示巨噬细胞随年龄增长而发生的这种变化的本质。讨论了巨噬细胞在疱疹病毒性脑炎发病机制中的作用。假设成熟小鼠巨噬细胞的改变在其对疱疹病毒脑炎的抗性发展中起重要作用。
The resistance to herpes virus encephalitis which develops with age was studied in mice using fluorescent antibody staining. Adult mice remained susceptible to intracerebral inoculation, and the infection of the central nervous system was identical with that found in immature mice. A "barrier" to the spread of virus inoculated extraneurally developed with maturation, and the limitation of spread appeared to coincide with the infection of peritoneal and tissue macrophages. In vitro, suckling and adult mouse macrophages were infected with equal ease. However, suckling mouse macrophages infected other cells in contact with them, while infected adult mouse macrophages did not. Studies failed to reveal the nature of this change in macrophages which developed with age. The role of macrophages in the pathogenesis of herpes virus encephalitis is discussed. The hypothesis is made that an alteration in the macrophages of the maturing mouse plays an important role in its development of resistance to herpes virus encephalitis.