Double-lumen central venous catheters impregnated with chlorhexidine and silver sulfadiazine to prevent catheter colonisation in the intensive care unit setting: a prospective randomised study
Double-lumen central venous catheters impregnated with chlorhexidine and silver sulfadiazine to prevent catheter colonisation in the intensive care unit setting: a prospective randomised study
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DOI：
10.1016/j.jhin.2009.03.018
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发表时间：
2009-07-01
影响因子：
6.9
通讯作者：
Edmond, M. B.
中科院分区：
文献类型：
--
作者：
Camargo, L. F. A.;Marra, A. R.;Edmond, M. B.
建议使用抗菌剂和防腐剂浸泡的导管来预防中心静脉导管(CVC)定植。有关重症监护病房(ICU)患者使用洗必泰/磺胺嘧啶银液浸泡的导尿管的报道很少。我们进行了一项前瞻性随机研究，比较了氯己定/磺胺嘧啶银浸渍的CVC(组1)和标准CVC(组2)的定殖率。为了评估导管定植率，用滚板法从无菌移除的导管末端4厘米处进行培养。总共有109例患者成功置管，其中51例在第1组，58例在第2组。在年龄、序贯方面，两组之间没有统计学差异。器官衰竭评估(SOFA)评分、ICU入院诊断、感染风险、导管插入部位或导管停留时间。第1组的定植率为29.4%(15根导管)，第2组为34.5%(20根导管)(P=0.50)。氯己定和磺胺嘧啶银双腔CVCs不能有效降低ICU患者导管定植的发生率。(C)2009年由爱思唯尔有限公司代表医院感染学会出版。
Antimicrobial- and antiseptic-impregnated catheters are strategies recommended to prevent central venous catheter (CVC) colonisation. Few data regarding chlorhexidine/silver sulfadiazine-impregnated catheters in intensive care unit (ICU) patients have been reported. We performed a prospective, randomised study comparing the colonisation rates of chlorhexidine/silver sulfadiazine-impregnated CVCs (group 1) against standard CVCs (group 2). In order to assess catheter colonisation rates, a 4 cm segment from the tips of aseptically removed catheters was cultured by the roll-plate method. In all, 109 patients were enrolled with successful catheter insertion, 51 of them in group 1 and 58 in group 2. There were no statistically significant differences between the two groups with regards to age, Sequential. Organ Failure Assessment (SOFA) score, ICU admission diagnosis, infection risk, catheter insertion sites or catheter length of stay. The colonisation rates were 29.4% (15 catheters) for group 1 and 34.5% (20 catheters) for group 2 (P = 0.50). Double-lumen CVCs impregnated with chlorhexidine and silver sulfadiazine were not effective in reducing the incidence of catheter colonisation in ICU patients. (c) 2009 Published by Elsevier Ltd on behalf of The Hospital Infection Society.