The effect of genistein on intracerebroventricular streptozotocin-induced cognitive deficits in male rat
The effect of genistein on intracerebroventricular streptozotocin-induced cognitive deficits in male rat
复制标题
金雀异黄素对脑室内链脲佐菌素所致雄性大鼠认知缺陷的影响
DOI：
--
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Tourandokht Balouchnejadmojarad
中科院分区：
文献类型：
--
作者：
Tourandokht Balouchnejadmojarad
方法：为此目的，大鼠双侧ICV STZ注射，在第1和第3天（3 mg/kg）。注射STZ的大鼠接受GEN（lmg/kg/天，p.o.）从手术前一天开始持续两周采用被动回避范式评价大鼠的学习记忆能力，采用放射状八臂迷宫（RAM）任务评价大鼠的空间认知能力。结果如下：发现GEN处理的注射STZ的大鼠在RAM中显示出比赋形剂处理的注射STZ的大鼠更高的正确选择和更低的错误。此外，GEN管理显着衰减的学习和记忆障碍在治疗STZ注射组在被动回避测试。讨论内容：这些结果证明GEN在预防大鼠中由ICV STZ引起的认知缺陷方面的有效性及其在治疗神经退行性疾病如阿尔茨海默病（AD）中的潜力。
Methods: For this purpose, rats were injected with ICV STZ bilaterally, on days 1 and 3 (3 mg/kg). The STZ-injected rats received GEN (1 mg/kg/day, p.o.) starting one day pre-surgery for two weeks. The learning and memory performance was assessed using passive avoidance paradigm, and for spatial cognition evaluation, radial eight-arm maze (RAM) task was used. Results: It was found out that GEN-treated STZ-injected rats show higher correct choices and lower errors in RAM than vehicle-treated STZ-injected rats. In addition, GEN administration significantly attenuated learning and memory impairment in treated STZ-injected group in passive avoidance test. Discussion: These results demonstrate the effectiveness of GEN in preventing the cognitive deficits caused by ICV STZ in rats and its potential in the treatment of neurodegenerative diseases such as Alzheimer’s disease (AD).
阿尔茨海默病形态学和胆碱能异常的大脑区域分析。
影响因子：
--
作者：
Zubenko,GS;Moossy,J;Martinez,AJ;Rao,GR;Kopp,U;Hanin,I
通讯作者：
Hanin,I