ENDOTOXIN CHALLENGE AFTER MENHADEN OIL DIET - EFFECTS ON SURVIVAL OF GUINEA-PIGS
ENDOTOXIN CHALLENGE AFTER MENHADEN OIL DIET - EFFECTS ON SURVIVAL OF GUINEA-PIGS
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DOI：
10.1093/ajcn/49.2.277
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发表时间：
1989-02-01
影响因子：
7.1
通讯作者：
BLACKBURN, GL
中科院分区：
文献类型：
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作者：
MASCIOLI, EA;IWASA, Y;BLACKBURN, GL
用环加氧酶抑制剂预处理后，内毒素存活率得到改善。由于鲱鱼油中的二十碳五烯酸 (EPA) 会竞争性抑制环加氧酶，因此我们给两组豚鼠喂食 6 周，其中脂肪来源为鲱鱼油或红花油。第三组允许随意食用红花油饮食。内毒素注射后 20 小时，与红花油对照动物相比，鲱鱼油喂养动物的存活率有所提高（87% vs 63%，p < 0.05）。随意饲喂红花油的动物存活率最低，20 小时时存活率为 47%（与鲱鱼油组相比，p < 0.005）。我们得出的结论是，喂养动物的主要脂质来源是鱼油的饮食可显着提高内毒素后的存活率。膳食脂肪不仅应被视为热量来源，而且应被视为一种药理活性物质，可以对宿主对毒性损伤的反应产生深远的影响。
Improvement in survival to endotoxin has been seen after pretreatment with cyclooxygenase inhibitors. Because eicosapentaenoic acid (EPA), found in menhaden oil, competitively inhibits cyclooxygenase, we fed two groups of guinea pigs diets, in which the fat source was either menhaden or safflower oil, for 6 wk. A third group was allowed the safflower oil diet ad libitum. Menhaden oil-fed animals showed enhanced survival compared with safflower oil control animals 20 h after endotoxin (87 vs 63%, p < 0.05). Ad libitum-fed safflower oil animals survived least well, with 47% alive at 20 h (p < 0.005 vs menhaden oil group). We conclude that feeding animals a diet whose predominant lipid source is fish oil significantly improves survival after endotoxin. Dietary fat should be viewed not only as a caloric source but as a pharmacologically active substance that can have profound effects on the host''s response to toxic insults.