Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome.
Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome.
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成人呼吸窘迫综合征患者支气管肺泡灌洗液中的中性粒细胞弹性蛋白酶释放因子。
DOI：
10.1164/arrd.1985.132.5.1098
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Cohen,AB
中科院分区：
文献类型：
--
作者：
Idell,S;Kucich,U;Fein,A;Kueppers,F;James,HL;Walsh,PN;Weinbaum,G;Colman,RW;Cohen,AB
支气管肺泡灌洗液（BAL）取自成人呼吸窘迫综合征（ARDS）患者。对照组包括正常受试者和结节病或肺纤维化患者的BAL。免疫学检测的神经弹性蛋白酶在所有的BAL标本中均有发现，但在ARDS患者的BAL中明显高于正常人或结节病患者的BAL。ARDS和肺纤维化患者BAL标本中性粒细胞弹性蛋白酶抗原浓度无显著差异。两组均未发现弹性蛋白溶解活性。ARDS患者的BAL中α-1-抗胰蛋白酶和支气管粘液抑制剂更高。急性呼吸窘迫综合征患者肺泡-动脉氧分压差与中性粒细胞弹性蛋白酶浓度呈高度显著相关。在ARDS患者的BAL中发现了激肽释放酶、前激肽释放酶、因子XIa样活性和高分子量激肽原抗原，表明激肽释放酶-激肽级联反应可能在ARDS患者的肺部被激活。来自ARDS患者的BAL中的激肽释放酶样活性与BAL中的中性粒细胞的数量、中性粒细胞弹性蛋白酶浓度以及BAL从细胞松弛素B处理的中性粒细胞释放弹性蛋白酶的能力显著相关。这些变量与C5 a浓度之间无相关性。这些研究表明BAL中性粒细胞弹性蛋白酶与ARDS患者的临床状态之间存在相关性。
Bronchoalveolar lavage fluid (BAL) was obtained from patients with adult respiratory distress syndrome (ARDS). Controls included BAL from normal subjects and from patients with sarcoidosis or pulmonary fibrosis. Neutrophil elastase measured immunologically was found in all BAL samples, but it was strikingly greater in BAL from patients with ARDS than in the BAL from normal subjects or patients with sarcoidosis. There was no significant difference in the neutrophil elastase antigen concentrations in BAL samples from patients with ARDS and those with pulmonary fibrosis. No elastolytic activity was found in either group. The alpha-1-antitrypsin and the bronchial mucus inhibitor were greater in BAL from patients with ARDS. There was a highly significant correlation between the alveolar-arterial oxygen tension difference and the neutrophil elastase concentration in BAL from the patients with ARDS. Kallikrein, prekallikrein, factor XIa-like activity, and high molecular weight kininogen antigen were found in BAL of patients with ARDS, suggesting that the kallikrein-kinin cascade may be activated in the lungs of patients with ARDS. Kallikrein-like activity in the BAL from the patients with ARDS was significantly correlated with the number of neutrophils in the BAL, the neutrophil elastase concentration, and the ability of the BAL to release elastase from cytochalasin-B-treated neutrophils. There was no correlation between these variables and C5a concentration. These studies demonstrated an association between BAL neutrophil elastase and the clinical state of patients with ARDS.
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影响因子：
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作者：
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DOI：
--
发表时间：
1983
期刊：
Journal of Laboratory and Clinical Medicine
影响因子：
--
作者：
F. Kueppers;B. Bromke
通讯作者：
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