Down‐regulation of calcium/calmodulin‐dependent protein kinase kinase 2 by androgen deprivation induces castration‐resistant prostate cancer
Down‐regulation of calcium/calmodulin‐dependent protein kinase kinase 2 by androgen deprivation induces castration‐resistant prostate cancer
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DOI：
10.1002/pros.22533
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发表时间：
2012-12
期刊：
影响因子：
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通讯作者：
Takashi Shima;A. Mizokami;Toru Miyagi;K. Kawai;K. Izumi;Misako Kumaki;Mitsuo Ofude;Jian Zhang;E. Keller;M. Namiki
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文献类型：
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作者：
Takashi Shima;A. Mizokami;Toru Miyagi;K. Kawai;K. Izumi;Misako Kumaki;Mitsuo Ofude;Jian Zhang;E. Keller;M. Namiki
ADT过程中向雄激素敏感状态的转化和对低雄激素浓度的适应导致前列腺癌（PCa）的复发。鉴别前列腺癌与正常前列腺组织之间的差异表达基因，并揭示这些基因在前列腺癌进展中所起的作用是非常重要的。
Conversion into androgen‐hypersensitive state and adaptation to the low concentration of androgen during ADT cause relapse of prostate cancer (PCa). It is important to identify differentially expressed genes between PCa and normal prostate tissues and to reveal the function of these genes that are involved in progression of PCa.