Dynamic gene expression in the song system of zebra finches during the song learning period.
Dynamic gene expression in the song system of zebra finches during the song learning period.
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斑胸草雀鸣叫系统在鸣叫学习期间的动态基因表达。
DOI：
10.1002/dneu.22286
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发表时间：
2015
影响因子：
3
通讯作者：
Mello,ClaudioV
中科院分区：
文献类型：
--
作者：
Olson,ChristopherR;Hodges,LisaK;Mello,ClaudioV
在幼年斑胸草雀的鸣叫学习期间，控制鸣叫学习和产生的大脑回路在形态和连接方面经历了显着的变化，与鸣叫的习得、练习和完善同时进行。然而，在这个关键的学习时期建立神经元连接性和可塑性的遗传程序和监管变化的时机在很大程度上仍然不确定。为了解决这个问题，我们使用原位杂交来比较成年和幼年雄性斑胸草雀在发育过程中不同年龄（孵化后 20、35、50 天，dph）的一组 30 种已知的 HVC 和/或 X 区（主要端脑歌曲核）分子标记的表达模式。我们发现，所检查的几个基因在 HVC 或其周围和/或其他歌曲核中的表达发生了显着变化。它们符合广泛的调节模式，包括在此期间 HVC 内表达增加的那些（COL12A1、COL 21A1、MPZL1、PVALB 和 CXCR7）或减少的（例如 KCNT2、SAP30L），以及一些在周围组织中表现出表达减少而在宋核内变化很小的（例如 SV2B、TAC1）。这些结果揭示了歌曲系统中与歌曲学习时期相关的广泛的分子变化。一些已确定的基因和途径是与鸣叫控制系统成年特性的出现和/或鸣禽学习发声的获得相关的发育变化的潜在调节剂。 © 2015 Wiley periodicals, Inc. 开发 Neurobiol 75: 1315–1338, 2015
The brain circuitry that controls song learning and production undergoes marked changes in morphology and connectivity during the song learning period in juvenile zebra finches, in parallel to the acquisition, practice and refinement of song. Yet, the genetic programs and timing of regulatory change that establish the neuronal connectivity and plasticity during this critical learning period remain largely undetermined. To address this question, we usedin situhybridization to compare the expression patterns of a set of 30 known robust molecular markers of HVC and/or area X, major telencephalic song nuclei, between adult and juvenile male zebra finches at different ages during development (20, 35, 50 days post‐hatch, dph). We found that several of the genes examined undergo substantial changes in expression within HVC or its surrounds, and/or in other song nuclei. They fit into broad patterns of regulation, including those whose expression within HVC during this period increases (COL12A1, COL 21A1, MPZL1, PVALB,andCXCR7) or decreases (e.g.,KCNT2, SAP30L), as well as some that show decreased expression in the surrounding tissue with little change within song nuclei (e.g. SV2B, TAC1). These results reveal a broad range of molecular changes that occur in the song system in concert with the song learning period. Some of the genes and pathways identified are potential modulators of the developmental changes associated with the emergence of the adult properties of the song control system, and/or the acquisition of learned vocalizations in songbirds. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 75: 1315–1338, 2015
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DOI：
10.1152/ajpregu.1985.249.1.r116
发表时间：
1985
期刊：
The American journal of physiology
影响因子：
--
作者：
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1975-01-01
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影响因子：
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作者：
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DOI：
--
发表时间：
1984
期刊：
Journal of developmental physiology
影响因子：
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D. J. Court;J. Parer;B. S. Block;A. Llanos
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